ArticleMolecular imaging and biology2010
Antioxidants improve early survival of cardiomyoblasts after transplantation to the myocardium.
Article in Molecular imaging and biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Identification of a Sesquiterpene Lactone fromMolecules (Basel, Switzerland) · 2021Article
- Pathway-specific reporter genes to study stem cell biology.Stem cells (Dayton, Ohio) · 2020Article
- Ginkgo Biloba L. Extract Reduces H2O2-Induced Bone Marrow Mesenchymal Stem Cells Cytotoxicity by Regulating Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways and Oxidative Stress.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Image-guided stem cells with functionalized self-assembling peptide nanofibers for treatment of acute myocardial infarction in a mouse model.American journal of translational research · 2017Article
- Effects of Antioxidant Supplements on the Survival and Differentiation of Stem Cells.Oxidative medicine and cellular longevity · 2017Review
- Sitagliptin ameliorates oxidative stress in experimental diabetic nephropathy by diminishing the miR-200a/Keap-1/Nrf2 antioxidant pathway.Diabetes, metabolic syndrome and obesity : targets and therapy · 2017Article
- Article
- Mesenchymal Stromal Cells Improve Renovascular Function in Polycystic Kidney Disease.Cell transplantation · 2015Article
- Molecular imaging of stem cells for the treatment of acute myocardial infarction.International journal of clinical and experimental medicine · 2015Article
- Renin inhibition improves the survival of mesenchymal stromal cells in a mouse model of myocardial infarction.Journal of cardiovascular translational research · 2014Article
- The cardiac regenerative potential of myoblasts remains limited despite improving their survival via antioxidant treatment.CellR4-- repair, replacement, regeneration, & reprogramming · 2014Article
- Article
- Molecular imaging: the key to advancing cardiac stem cell therapy.Trends in cardiovascular medicine · 2013Review
- Noninvasive monitoring of oxidative stress in transplanted mesenchymal stromal cells.JACC. Cardiovascular imaging · 2013Article
- Article
- Polycystic kidneys have decreased vascular density: a micro-CT study.Microcirculation (New York, N.Y. : 1994) · 2013Article
- Characterization of superoxide dismutases in cardiac progenitor cells demonstrates a critical role for manganese superoxide dismutase.Stem cells and development · 2012Article
- MicroRNA-1 transfected embryonic stem cells enhance cardiac myocyte differentiation and inhibit apoptosis by modulating the PTEN/Akt pathway in the infarcted heart.American journal of physiology. Heart and circulatory physiology · 2011Article
- Role of oxidative stress in hypoxia preconditioning of cells transplanted to the myocardium: a molecular imaging study.The Journal of cardiovascular surgery · 2011Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
purposeWe tested the hypothesis that modulation of the microenvironment (using antioxidants) will increase stem cell survival in hypoxia and after transplantation to the myocardium. PROCEDURES: Rat cardiomyoblasts were stably transfected with a reporter gene (firefly luciferase) for bioluminescence imaging (BLI). First, we examined the role of oxidative stress in cells under hypoxic conditions. Subsequently, stem cells were transplanted to the myocardium of rats using high-resolution ultrasound, and their survival was monitored daily using BLI.
resultsUnder hypoxia, oxidative stress was increased together with decreased cell survival compared to control cells, both of which were preserved by antioxidants. In living subjects, oxidative stress blockade increased early cell survival after transplantation to the myocardium, compared to untreated cells/animals.
conclusionModulation of the local microenvironment (with antioxidants) improves stem cell survival. Increased understanding of the interaction between stem cells and their microenvironment will be critical to advance the field of regenerative medicine.
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