ReviewCellular and molecular life sciences : CMLS2010
Platelets in defense against bacterial pathogens.
Review in Cellular and molecular life sciences : CMLS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03989609 (ROle of Dexmedetomidine in Modifying Immune Paralysis In Patient With Septic Shock), which is not on this map. Cited by 132 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ROle of Dexmedetomidine in Modifying Immune Paralysis In Patient With Septic Shock: Randomized Controlled Trial (RODIS Trial)
Who cites it
132 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic literature review evaluating evidence and mechanisms of action for platelet-rich plasma as an antibacterial agent.Journal of cardiothoracic surgery · 2021Pooled it
- Combinatorial phenotypic signatures distinguish persistent from resolving methicillin-resistant Staphylococcus aureus bacteremia isolates.Antimicrobial agents and chemotherapy · 2011Trial
- Biomimetic Cell Membrane-Based Drug Delivery Systems for Oral Diseases: Engineering Strategies, Targeting Mechanisms, and Translational Challenges.Pharmaceutics · 2026Review
- Pre-operative antiplatelet therapy is associated with increased risk of periprosthetic joint infection following total shoulder arthroplasty.Journal of shoulder and elbow arthroplasty · 2026Article
- Low Preoperative Platelet Count Is Associated With Deep Surgical Site Infection in Knee Arthroplasty.Arthroplasty today · 2026Article
- The antimicrobial effects of cord blood-derived platelet gel on nosocomial pathogens.Iranian journal of microbiology · 2026Article
- Combined analysis of host immune response, biofilm genes, and 16S rRNA detection in fracture-related infection: an observational cohort study.Journal of bone and joint infection · 2026Article
- Antibacterial and antibiofilm activity of platelet-rich plasma under different activation conditions against multidrug-resistant MRSA isolated from human skin abscesses.BMC biotechnology · 2025Article
- The impact of thrombocytopenia on mortality in infective endocarditis - aInternational journal of cardiology. Heart & vasculature · 2025Review
- Technology Roadmap of Micro/Nanorobots.ACS nano · 2025Review
- Anti-bacterial activity of dermcidin in human platelets: suppression of methicillin-resistantMicrobiology spectrum · 2025Article
- Aging-associated changes in immunological parameters: Implications for COVID-19 immune response in the elderly.Physiological reports · 2025Review
- Nanomaterials for targeted therapy of kidney diseases: Strategies and advances.Materials today. Bio · 2025Review
- Neutrophils: Linking Inflammation to Thrombosis and Unlocking New Treatment Horizons.International journal of molecular sciences · 2025Review
- Platelets in infection: intrinsic roles and functional outcomes.Frontiers in immunology · 2025Review
- Antifungal Innate Immunity.Advances in experimental medicine and biology · 2025Review
- Clinical and molecular features of candidemia: a three-year retrospective study in Northern Guizhou, China.Frontiers in cellular and infection microbiology · 2025Article
- Review
- Subphenotypes of platelet count trajectories in sepsis from multi-center ICU data.Scientific reports · 2024Observational
- Factors associated with the time required for CRP normalization in pyogenic spondylitis: A retrospective observational study.North American Spine Society journal · 2024Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Platelets interact with bacterial pathogens through a wide array of cellular and molecular mechanisms. The consequences of this interaction may significantly influence the balance between infection and immunity. On the one hand, recent data indicate that certain bacteria may be capable of exploiting these interactions to gain a virulence advantage. Indeed, certain bacterial pathogens appear to have evolved specific ways in which to subvert activated platelets. Hence, it is conceivable that some bacterial pathogens exploit platelet responses. On the other hand, platelets are now known to possess unambiguous structures and functions of host defense effector cells. Recent discoveries emphasize critical features enabling such functions, including expression of toll-like receptors that detect hallmark signals of bacterial infection, an array of microbicidal peptides, as well as other host defense molecules and functions. These concepts are consistent with increased risk and severity of bacterial infection as correlates of clinical abnormalities in platelet quantity and quality. In these respects, the molecular and cellular roles of platelets in host defense against bacterial pathogens are explored with attention on advances in platelet immunobiology.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.