ArticleMammalian genome : official journal of the International Mammalian Genome Society2010
Identification of novel chromosomal regions associated with airway hyperresponsiveness in recombinant congenic strains of mice.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Family-based genome-wide association study for asthma among Han Chinese children.BMC pediatrics · 2026Article
- Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Mouse Chromosome 4 Is Associated with the Baseline and Allergic IgE Phenotypes.G3 (Bethesda, Md.) · 2017Article
- Plethysmography Phenotype QTL in Mice Before and After Allergen Sensitization and Challenge.G3 (Bethesda, Md.) · 2016Article
- Article
- A cautionary note on ignoring polygenic background when mapping quantitative trait loci via recombinant congenic strains.Frontiers in genetics · 2014Article
- Article
- The down-regulation of GNAO1 and its promoting role in hepatocellular carcinoma.Bioscience reports · 2013Article
- Association of FANCC polymorphisms with FEV1 decline in aspirin exacerbated respiratory disease.Molecular biology reports · 2012Article
- Genetic interactions between chromosomes 11 and 18 contribute to airway hyperresponsiveness in mice.PloS one · 2012Article
- Identification of the Mhc region as an asthma susceptibility locus in recombinant congenic mice.American journal of respiratory cell and molecular biology · 2011Article
- Multiple imputation of missing phenotype data for QTL mapping.Statistical applications in genetics and molecular biology · 2011Article
- Strain-specific differences in the genetic control of two closely related mycobacteria.PLoS pathogens · 2010Article
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Authors and funding
7 authors.
Funding
Abstract
Airway responsiveness is the ability of the airways to respond to bronchoconstricting stimuli by reducing their diameter. Airway hyperresponsiveness has been associated with asthma susceptibility in both humans and murine models, and it has been shown to be a complex and heritable trait. In particular, the A/J mouse strain is known to have hyperresponsive airways, while the C57BL/6 strain is known to be relatively refractory to bronchoconstricting stimuli. We analyzed recombinant congenic strains (RCS) of mice generated from these hyper- and hyporesponsive parental strains to identify genetic loci underlying the trait of airway responsiveness in response to methacholine as assessed by whole-body plethysmography. Our screen identified 16 chromosomal regions significantly associated with airway hyperresponsiveness (genome-wide P <or= 0.05): 8 are supported by independent and previously published reports while 8 are entirely novel. Regions that overlap with previous reports include two regions on chromosome 2, three on chromosome 6, one on chromosome 15, and two on chromosome 17. The 8 novel regions are located on chromosome 1 (92-100 cM), chromosome 5 (>73 cM), chromosome 7 (>63 cM), chromosome 8 (52-67 cM), chromosome 10 (3-7 cM and >68 cM), and chromosome 12 (25-38 cM and >52 cM). Our data identify several likely candidate genes from the 16 regions, including Ddr2, Hc, Fbn1, Flt3, Utrn, Enpp2, and Tsc.
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