ArticleBehavior genetics2010
A genome-wide association study of social and non-social autistic-like traits in the general population using pooled DNA, 500 K SNP microarrays and both community and diagnosed autism replication samples.
Article in Behavior genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 56 citations in OpenAlex.
- Systematic Review and Meta-Analysis: Phenotypic Correlates of the Autism Polygenic Score.JAACAP open · 2025Article
- Knowledge mapping of autistic traits: a visual analysis via CiteSpace.Frontiers in psychiatry · 2025Review
- Two Decades of Accomplishment and Progress in Behavior Genetics.Behavior genetics · 2024Article
- Genetics and epigenetics of autism spectrum disorder-current evidence in the field.Journal of applied genetics · 2019Review
- Childhood behaviour problems show the greatest gap between DNA-based and twin heritability.Translational psychiatry · 2017Article
- Gene-set analysis shows association between FMRP targets and autism spectrum disorder.European journal of human genetics : EJHG · 2017Article
- Candidate Biomarkers in Children with Autism Spectrum Disorder: A Review of MRI Studies.Neuroscience bulletin · 2017Review
- The Genetic Overlap of Attention-Deficit/Hyperactivity Disorder and Autistic-like Traits: an Investigation of Individual Symptom Scales and Cognitive markers.Journal of abnormal child psychology · 2016Article
- Where are the strongest associations between autistic traits and traits of ADHD? evidence from a community-based twin study.European child & adolescent psychiatry · 2015Article
- Heritability of Autism Spectrum Disorder in a UK Population-Based Twin Sample.JAMA psychiatry · 2015Article
- MACROD2 gene associated with autistic-like traits in a general population sample.Psychiatric genetics · 2014Article
- Language and traits of autism spectrum conditions: evidence of limited phenotypic and etiological overlap.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014Article
- Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.Molecular autism · 2014Article
- Biomarkers in autism.Frontiers in psychiatry · 2014Review
- Association study between autistic-like traits and polymorphisms in the autism candidate regions RELN, CNTNAP2, SHANK3, and CDH9/10.Molecular autism · 2014Article
- Factor structure of autistic traits in children with ADHD.Journal of autism and developmental disorders · 2014Article
- Common variation contributes to the genetic architecture of social communication traits.Molecular autism · 2013Article
- Changing concepts and findings on autism.Journal of autism and developmental disorders · 2013Review
- Prenatal stress delays inhibitory neuron progenitor migration in the developing neocortex.Psychoneuroendocrinology · 2013Article
- Autism spectrum disorders.European child & adolescent psychiatry · 2013Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Two separate genome-wide association studies were conducted to identify single nucleotide polymorphisms (SNPs) associated with social and nonsocial autistic-like traits. We predicted that we would find SNPs associated with social and non-social autistic-like traits and that different SNPs would be associated with social and nonsocial. In Stage 1, each study screened for allele frequency differences in approximately 430,000 autosomal SNPs using pooled DNA on microarrays in high-scoring versus low-scoring boys from a general population sample (N = approximately 400/group). In Stage 2, 22 and 20 SNPs in the social and non-social studies, respectively, were tested for QTL association by individually genotyping an independent community sample of 1,400 boys. One SNP (rs11894053) was nominally associated (P < .05, uncorrected for multiple testing) with social autistic-like traits. When the sample was increased by adding females, 2 additional SNPs were nominally significant (P < .05). These 3 SNPs, however, showed no significant association in transmission disequilibrium analyses of diagnosed ASD families.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.