ArticleBiomedical microdevices2010
An electrically active microneedle array for electroporation.
Article in Biomedical microdevices, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 126 citations in OpenAlex.
- Gas-propelled microneedles for precision transdermal therapeutics.Bioactive materials · 2027Review
- Noninvasive Monitoring of Skin pH Changes Induced by Microneedle Electroporation.Sensors and actuators. B, Chemical · 2026Article
- Microneedle-Based Biofuel Cell with MXene/CNT Hybrid Bioanode: Fundamental and Biomedical Application.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Recent advances in electric-stimulus assisted microneedle patches for skin disease treatment.Journal of nanobiotechnology · 2025Review
- Active microneedle patch equipped with spontaneous bubble generation for enhanced rheumatoid arthritis treatment.Theranostics · 2025Article
- Erythrocytes Nanoparticle Delivery: A Boon for Targeting Tumor.Advanced pharmaceutical bulletin · 2024Review
- Tissue Nanotransfection Silicon Chip and Related Electroporation-Based Technologies for In Vivo Tissue Reprogramming.Nanomaterials (Basel, Switzerland) · 2024Review
- Metallic Microneedles for Transdermal Drug Delivery: Applications, Fabrication Techniques and the Effect of Geometrical Characteristics.Bioengineering (Basel, Switzerland) · 2022Review
- Microneedle-based ocular drug delivery systems - recent advances and challenges.Beilstein journal of nanotechnology · 2022Review
- Invasive and non-invasive electrodes for successful drug and gene delivery in electroporation-based treatments.Frontiers in bioengineering and biotechnology · 2022Review
- Microneedle systems for delivering nucleic acid drugs.Journal of pharmaceutical investigation · 2022Review
- An ultra-low-cost electroporator with microneedle electrodes (ePatch) for SARS-CoV-2 vaccination.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Manufacturing Process of Polymeric Microneedle Sensors for Mass Production.Micromachines · 2021Article
- Bio-Nanocarriers for Lung Cancer Management: Befriending the Barriers.Nano-micro letters · 2021Review
- Microneedles Drug Delivery Systems for Treatment of Cancer: A Recent Update.Pharmaceutics · 2020Review
- Active Microneedle Administration of Plant Virus Nanoparticles for CancerACS applied nano materials · 2020Article
- Built-In Active Microneedle Patch with Enhanced Autonomous Drug Delivery.Advanced materials (Deerfield Beach, Fla.) · 2020Article
- Microneedle Patterning of 3D Nonplanar Surfaces on Implantable Medical Devices Using Soft Lithography.Micromachines · 2019Article
- Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application.Acta pharmaceutica Sinica. B · 2019Review
- Inductively actuated micro needles for on-demand intracellular delivery.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
We have designed and fabricated a microneedle array with electrical functionality with the final goal of electroporating skin's epidermal cells to increase their transfection by DNA vaccines. The microneedle array was made of polymethylmethacrylate (PMMA) by micromolding technology from a polydimethylsiloxane (PDMS) mold, followed by metal deposition, patterning using laser ablation, and electrodeposition. This microneedle array possessed sufficient mechanical strength to penetrate human skin in vivo and was also able to electroporate both red blood cells and human prostate cancer cells as an in vitro model to demonstrate cell membrane permeabilization. A computational model to predict the effective volume for electroporation with respect to applied voltages was constructed from finite element simulation. This study demonstrates the mechanical and electrical functionalities of the first MEMS-fabricated microneedle array for electroporation, designed for DNA vaccine delivery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.