Evidence map›Paper›PMID 20012514›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Advances in radionuclide molecular imaging in myocardial biology.

Alan R Morrison, Albert J Sinusas

Open access · greenAbstract read
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Cardiac autonomic imaging with SPECT tracers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013
    Review
  3. A key role for nuclear cardiac imaging in evaluating and managing patients with heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012
    Article
  4. Article
  5. Targeted molecular imaging of angiogenesis in PET and SPECT: a review.The Yale journal of biology and medicine · 2012
    Review
  6. Targeting angiogenesis using a C-type atrial natriuretic factor-conjugated nanoprobe and PET.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alan R MorrisonSection of Cardiovascular Medicine, Department of Medicine, Yale University School of Medicine, P.O. Box 208017, New Haven, CT 06520-8017, USA.
Albert J Sinusas
Yale University · US

Funding

Non-Invasive Methods for Imaging Myocardial AngiogenesisR01HL065662 · NHLBI · YALE UNIVERSITY · PI SINUSAS, ALBERT J · 2001 to 2009
$3.2M
Imaging of MMP activation and myocardial strainsR01HL078650 · NHLBI · YALE UNIVERSITY · PI SINUSAS, ALBERT J · 2004 to 2007
$2.3M
The Rac-2-induced macrophage proteome and vascular pathologyF32HL097422 · NHLBI · YALE UNIVERSITY · PI MORRISON, ALAN ROSS · 2009 to 2011
$168k
NHLBI NIH HHS F32 HL097422NHLBI NIH HHS L30 HL115713NHLBI NIH HHS R01 HL065662NHLBI NIH HHS R01 HL078650
6 · The paper itself

Abstract

Molecular imaging is a new and evolving field that employs a targeted approach to noninvasively assess biologic processes in vivo. By assessing key elements in specific cellular processes prior to irreversible end-organ damage, molecular tools will allow for earlier detection and intervention, improving management and outcomes associated with cardiovascular diseases. The goal of those working to expand this field is not just to provide diagnostic and prognostic information, but rather to guide an individual's pharmacological, cell-based, or genetic therapeutic regimen. This article will review molecular imaging tools in the context of our current understanding of biological processes of the myocardium, including angiogenesis, ventricular remodeling, inflammation, and apoptosis. The focus will be on radiotracer-based molecular imaging modalities with an emphasis on clinical application. Though this field is still in its infancy and may not be fully ready for widespread use, molecular imaging of myocardial biology has begun to show promise of clinical utility in acute and chronic ischemia, acute myocardial infarction, congestive heart failure, as well as in more global inflammatory and immune-mediated responses in the heart-like myocarditis and allogeneic cardiac transplant rejection. With continued research and development, molecular imaging promises to be an important tool for the optimization of cardiovascular care.

Indexed as

RadioisotopesCardiologyCardiovascular DiseasesHumansMolecular Probe TechniquesNuclear MedicineTomography, Emission-ComputedRadioisotopes

Identifiers

PMID20012514
PMCPMC2823801
OpenAlexW2067432264

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.