ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2010
Association of the tumor necrosis factor-alpha -308 G/A polymorphism with nasal polyposis.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Genetic polymorphisms of cytokine genes and their role in the susceptibility and severity of allergic fungal rhinosinusitis.Archives of microbiology · 2025Article
- Insights into the epigenetics of chronic rhinosinusitis with and without nasal polyps: a systematic review.Frontiers in allergy · 2023Review
- Whole-Genome Resequencing to Study Brucellosis Susceptibility in Sheep.Frontiers in genetics · 2021Article
- C-590T Promoter Polymorphism of the Interleukin (IL)-4 Gene Is Associated with an Increased usceptibility to Nasal Polyposis.Reports of biochemistry & molecular biology · 2019Article
- TNF-alpha G/A308 polymorphism association with nasal polyposis in North part of Iran.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Article
- A Study of Single Nucleotide Polymorphisms of Tumour Necrosis Factor α-1031 And Tumour Necrosis Factor β+ 252 in Chronic Rhinosinusitis.Clinical and experimental otorhinolaryngology · 2017Article
- TNF-α and IL-1 β Cytokine Gene Polymorphism in Patients with Nasal Polyposis.Turkish archives of otorhinolaryngology · 2017Article
- "Cumulative Stress": The Effects of Maternal and Neonatal Oxidative Stress and Oxidative Stress-Inducible Genes on Programming of Atopy.Oxidative medicine and cellular longevity · 2016Review
- Risk factors for chronic rhinosinusitis.Current opinion in allergy and clinical immunology · 2015Review
- ICON: chronic rhinosinusitis.The World Allergy Organization journal · 2014Article
- Genetics of chronic rhinosinusitis: state of the field and directions forward.The Journal of allergy and clinical immunology · 2013Review
- The association between polymorphisms in the MRPL4 and TNF-α genes and susceptibility to allergic rhinitis.PloS one · 2013Article
- Genetics of rhinosinusitis.Current allergy and asthma reports · 2011Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nasal polyposis (NP) is a chronic inflammatory disease in which several molecular and cellular interactions play important roles. Tumor necrosis factor-alpha (TNF-alpha) is a major pro-inflammatory cytokine with a key role in immune inflammatory responses in NP. Altered levels of TNF-alpha, which may occur due to polymorphisms in the TNF-alpha promoter region, may also be associated with NP susceptibility. Given these facts, we investigated the possible association of the TNF-alpha -308 G/A single nucleotide polymorphism (SNP) with NP. In this study, 97 consecutive adult patients with NP and 95 age- and gender-matched controls were recruited. For identification of SNP, restriction fragment length polymorphism analysis after polymerase chain reaction was carried out. The NP group had a significantly higher rate of polymorphism compared to controls (p = 0.015). Logistic regression analysis revealed that the presence of the TNF-alpha -308 G/A SNP is an independent risk factor for NP development (OR, 3.68; CI, 1.27-10.7; p = 0.016). The presence of a mutation failed to influence disease severity on the basis of resistance to medical and/or surgical treatment. This study suggests a possible linkage of a SNP in the TNF-alpha promoter with NP. These results need to be confirmed with multicentre studies for more precise interpretation and corroborative studies for investigating the influence of polymorphism on transcriptional activity.
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