Evidence map›Paper›PMID 20012414›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2010

Computational approaches to the detection and analysis of sequences with intramolecular G-quadruplex forming potential.

Paul Ryvkin, Steve G Hershman, Li-San Wang, F Brad Johnson

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Fundamentals of G-quadruplex biology.Annual reports in medicinal chemistry · 2020
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Paul RyvkinDepartment of Pathology, Penn Center for Bioinformatics, and Graduate Group in Genomics and Computational Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Steve G Hershman
Li-San Wang
F Brad Johnson
University of Pennsylvania · USInstitute on Aging · US

Funding

STRUCTURAL BASIS FOR EPIGENETICS IN AGING AND LONGEVITYP01AG031862 · NIA · WISTAR INSTITUTE · PI GARCIA, BENJAMIN A · 2008 to 2022
$28.3M
Telomere maintenance by Werner syndrome family proteins.R01AG021521 · NIA · UNIVERSITY OF PENNSYLVANIA · PI JOHNSON, F. BRAD · 2004 to 2013
$2.8M
NIA NIH HHS P01 AG031862NIA NIH HHS P01-AG031862NIA NIH HHS R01 AG021521NIA NIH HHS R01-AG021521
6 · The paper itself

Abstract

Sequences with the potential to form intramolecular G-quadruplexes (G4-structures) are found in highly nonrandom distributions in the genomes of diverse organisms. These sequences are associated with nucleic acid metabolic processes ranging from transcription and translation to recombination and telomere function. Here we review different computational methods for identifying potential G4-forming sequences and provide protocols for their implementation. We also discuss methods for assessing the significance and specificity of associations between the sequences and different biological functions.

Indexed as

G-QuadruplexesComputational BiologyDNA PrimersGuanineHumansDNA PrimersGuanine

Identifiers

PMID20012414
PMCPMC3713069
OpenAlexW2196839244

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.