ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2010
Delay in diagnostic workup and treatment of esophageal cancer.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Cancer diagnostic tools to aid decision-making in primary care: mixed-methods systematic reviews and cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2020Pooled it
- Diagnostic value of symptoms of oesophagogastric cancers in primary care: a systematic review and meta-analysis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2015Pooled it
- Is increased time to diagnosis and treatment in symptomatic cancer associated with poorer outcomes? Systematic review.British journal of cancer · 2015Pooled it
- Association between Surgical Waiting Time and Postoperative Recurrence Risk in Clinical T1bN0M0 Thoracic Esophageal Squamous Cell Carcinoma: A Multicenter Retrospective Observational Study.Annals of surgical oncology · 2026Observational
- Hyperspectral reconstruction of white light endoscopy images for enhanced segmentation of early esophageal lesions in patients.iScience · 2026Article
- Short-term impact of delayed surgical treatment on the prognosis of patients with T1bN1-stage PTC: a retrospective cohort study.BMC cancer · 2025Article
- Association between surgery treatment delays and survival outcomes in patients with esophageal cancer in Hebei, China.Frontiers in oncology · 2024Article
- Influence of a patient navigation program on timeliness of care in patients with esophageal cancer.Cancer medicine · 2023Article
- Determinants of survival outcomes among esophageal cancer patients at a national referral hospital in Kenya.Chronic diseases and translational medicine · 2023Article
- Time to treatment of esophageal cancer in Ontario: A population-level cross-sectional study.JTCVS open · 2022Article
- Psychological distress among elderly surgical patients who had their surgery postponed during the COVID-19 pandemic.Perioperative medicine (London, England) · 2022Article
- Chemotherapy predictors and a time-dependent chemotherapy effect in metastatic esophageal cancer.World journal of gastrointestinal oncology · 2022Article
- Palliative radiotherapy and quality of life in patients with locally advanced thoracic esophageal cancer: a single centre experience from Central India.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022Article
- HOXA13 in etiology and oncogenic potential of Barrett's esophagus.Nature communications · 2021Article
- Understanding health-seeking and adherence to treatment by patients with esophageal cancer at the Uganda cancer Institute: a qualitative study.BMC health services research · 2021Article
- GATA4 blocks squamous epithelial cell gene expression in human esophageal squamous cells.Scientific reports · 2021Article
- Data from a large Western centre exploring the impact of COVID-19 pandemic on endoscopy services and cancer diagnosis.Frontline gastroenterology · 2021Article
- Time to surgery in thoracic cancers and prioritization during COVID-19: a systematic review.Journal of thoracic disease · 2020Article
- A scoping review of the impact of COVID-19 pandemic on surgical practice.Annals of medicine and surgery (2012) · 2020Article
- The impact of the COVID-19 pandemic on cancer deaths due to delays in diagnosis in England, UK: a national, population-based, modelling study.The Lancet. Oncology · 2020Article
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Abstract
introductionEsophageal cancer should preferably be detected and treated at an early stage, but this may be prohibited by late onset of symptoms and delays in referral, diagnostic workup, and treatment. The aim of this study was to investigate the impact of these delays on outcome in patients with esophageal cancer.
methodsFor 491 patients undergoing esophagectomy for cancer between 1991 and 2007, patients' short- and long-term outcome were analyzed according to different time intervals between onset of symptoms, diagnosis, and surgical treatment.
resultsLength of prehospital delay (from onset of symptoms until endoscopic diagnosis) did not affect patient's short- or long-term outcome. A shorter hospital delay between establishing the diagnosis of esophageal cancer on endoscopy and surgery was associated with lower overall morbidity and in-hospital mortality. Patients of ASA classes I and II experienced a shorter hospital delay than patients of ASA classes III and IV. Length of hospital delay between endoscopic diagnosis and surgery did not affect pathological tumor-node-metastasis stage or R0-resection rate. Longer hospital delay did not result in worse survival: Overall survival after esophagectomy for cancer was not significantly different between patients with hospital delay <5, 5-8, or >8 weeks (24.7%, 21.7%, and 32.3%, respectively; p = 0.12).
conclusionA longer hospital delay (between endoscopic diagnosis and surgery) resulted in worse patient's short-term outcome (higher overall morbidity and mortality rates) but not in a worse long-term outcome (overall survival). This may be explained by a more time-consuming diagnostic workup in patients with a poorer physical status and not by tumor progression.
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