ArticleFamilial cancer2010
Mismatch repair protein expression and colorectal cancer in Hispanics from Puerto Rico.
Article in Familial cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Microsatellite instability and mismatch repair deficiency prevalence among Hispanic/Latino individuals with colorectal cancer: a systematic review and meta-analysis.International journal of colorectal disease · 2026Pooled it
- Pharmacogenetic research activity in Central America and the Caribbean: a systematic review.Pharmacogenomics · 2016Pooled it
- Characterization of the Hispanic or latino population in health research: a systematic review.Journal of immigrant and minority health · 2014Pooled it
- Molecular profiling of colorectal cancer in a genetically admixed Hispanic population.Cancer medicine · 2023Article
- Gut microbiota distinct between colorectal cancers with deficient and proficient mismatch repair: A study of 230 CRC patients.Frontiers in microbiology · 2022Article
- Implementation of Universal Colorectal Cancer Screening for Lynch Syndrome in Hispanics Living in Puerto Rico.Journal of racial and ethnic health disparities · 2021Article
- Observational
- Detection of DNA Mismatch Repair Protein Abnormalities in Sudanese Colorectal Cancer Patients Using Immunohistochemical Methods.Journal of gastrointestinal cancer · 2019Article
- Expression status of four mismatch repair proteins in patients with colorectal cancer: clinical significance in 1238 cases.International journal of clinical and experimental pathology · 2019Article
- Low Referral Rate for Genetic Testing in Racially and Ethnically Diverse Patients Despite Universal Colorectal Cancer Screening.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2018Article
- DNA mismatch repair deficiency and hereditary syndromes in Latino patients with colorectal cancer.Cancer · 2017Article
- A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America.BMC cancer · 2017Article
- Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer.Oncotarget · 2017Article
- Clinical and Molecular Characteristics of Post-Colonoscopy Colorectal Cancer: A Population-based Study.Gastroenterology · 2016Article
- Validation of Prediction Models for Mismatch Repair Gene Mutations in Koreans.Cancer research and treatment · 2016Article
- Variability in Cancer Risk and Outcomes Within US Latinos by National Origin and Genetic Ancestry.Current epidemiology reports · 2016Review
- Clinical characterization and mutation spectrum in Caribbean Hispanic families with Lynch syndrome.Familial cancer · 2015Article
- Improving cancer clinical research and trials with Hispanic populations: training and outreach efforts between Moffitt Cancer Center and the Ponce School of Medicine.Reviews on recent clinical trials · 2014Article
- Report of a Novel Mutation in MLH1 Gene in a Hispanic Family from Puerto Rico Fulfilling Classic Amsterdam Criteria for Lynch Syndrome.Gastroenterology research and practice · 2014Article
- Microsatellite instability testing in Korean patients with colorectal cancer.Familial cancer · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Colorectal cancer (CRC) is a leading cause of morbidity and mortality and alterations in mismatch repair (MMR) genes, leading to absent protein (negative) expression, are responsible for approximately 20% of CRC cases. Immunohistochemistry is a tool for prescreening of MMR protein expression in CRC but the literature on its use on Hispanics is scarce. However, Hispanics represent the second leading ethnicity in the United States (US) and CRC is a public health burden in this group. Our objectives were to determine the frequency of MMR protein-negative CRC and to evaluate its association with clinical and pathological characteristics among Hispanics from Puerto Rico, for the first time to our knowledge. A retrospective observational study of unselected CRC patients from the Puerto Rico Medical Center from 2001 to 2005 was done. MLH1 and MSH2, the most commonly altered MMR genes, protein expression was evaluated using immunohistochemistry, with microsatellite instability (MSI) and BRAF gene analyses in the absence of MLH1 protein expression. One-hundred sixty-four CRC patients were evaluated: the overall MMR protein-negative frequency was 4.3%, with 0.6% frequency of co-occurrence of MLH1-protein negative expression, MSI-high, and normal BRAF gene. MMR protein-negative expression was associated with proximal colon location (P = 0.02) and poor histological tumor differentiation (P = 0.001), but not with other characteristics. The frequency of MMR protein-negative CRC in Hispanics from Puerto Rico was lower than reported in other populations. This finding may explain the lower CRC incidence rate among US Hispanics as compared to US non-Hispanic whites and blacks.
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