ArticleNaunyn-Schmiedeberg's archives of pharmacology2010
Tramadol-induced seizurogenic effect: a possible role of opioid-dependent histamine H1 receptor activation-linked mechanism.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Therapeutic implications of cyclooxygenase (COX) inhibitors in ischemic injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Pooled it
- COVID-19-Associated acute respiratory distress syndrome (CARDS): Mechanistic insights on therapeutic intervention and emerging trends.International immunopharmacology · 2021Pooled it
- Emerging perspectives on mitochondrial dysfunctioning and inflammation in epileptogenesis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Pooled it
- Seizures Following Single-Dose Intravenous Tramadol for Postsurgical Pain: A Report of Two Cases.Cureus · 2025Article
- Impact of Bioactive Compounds in the Management of Various Inflammatory Diseases.Current pharmaceutical design · 2024Review
- Tramadol poisoning and its management and complications: a scoping review.Annals of medicine and surgery (2012) · 2023Article
- Correlation of covid-19 and Guillain-Barré syndrome: A Mechanistic Perspective.Obesity medicine · 2023Review
- Association Between Opioid Use Disorder and Seizure Incidents Among Alcohol Use Disorder Patients.Substance abuse : research and treatment · 2023Article
- Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Pharmacological modulation of cytokines correlating neuroinflammatory cascades in epileptogenesis.Molecular biology reports · 2022Review
- Anticonvulsive Effects of Chondroitin Sulfate on Pilocarpine and Pentylenetetrazole Induced Epileptogenesis in Mice.Molecules (Basel, Switzerland) · 2021Article
- Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-ɣ): Molecular Effects and Its Importance as a Novel Therapeutic Target for Cerebral Ischemic Injury.Neurochemical research · 2021Review
- Dysbiosis and Alzheimer's Disease: A Role for Chronic Stress?Biomolecules · 2021Review
- Risk of Seizure after Naloxone Therapy in Acute Tramadol Poisoning: A Systematic Review with Meta-Analysis.International journal of preventive medicine · 2019Article
- Molecular Mechanism Involved in the Pathogenesis of Early-Onset Epileptic Encephalopathy.Frontiers in molecular neuroscience · 2019Article
- Evaluating the Anti-nociceptive and Anti-inflammatory Effects of Ketotifen and Fexofenadine in Rats.Advanced pharmaceutical bulletin · 2015Article
- Does naloxone prevent seizure in tramadol intoxicated patients?International journal of preventive medicine · 2014Article
- Targeting inflammation as a therapeutic strategy for drug-resistant epilepsies: an update of new immune-modulating approaches.Human vaccines & immunotherapeutics · 2014Review
- Health outcomes in patients using no-prescription online pharmacies to purchase prescription drugs.Journal of medical Internet research · 2012Article
- Neuro-inflammation, blood-brain barrier, seizures and autism.Journal of neuroinflammation · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study has been designed to investigate the role of opioid receptors, mast cells, and histamine receptors (H(1) subtype) in the seizurogenic effect of tramadol on pentylenetetrazole-treated mice. A single injection of pentylenetetrazole (80 mg kg(-1)) was used to elicit seizure activity in mice. Seizures were assessed in terms of the time latency of the onset of Straub-like tail, onset of jerky movements of whole body, convulsions, and death. Tramadol administration (50 mg kg (-1)) caused a marked increase in seizurogenic activity of pentylenetetrazole as measured in terms of a significant decrease in the time latency of the onset of Straub-like tail, jerky movements of whole body, convulsions, and death. Moreover, prior administration of naloxone (2 mg kg(-1)), fexofenadine (100 mg kg(-1)), cetrizine, sodium cromoglycate, and ketotifen (10 mg kg(-1)), respectively, attenuated the seizurogenic activity that tramadol exerted on pentylenetetrazole-treated mice. Therefore, it may be suggested that tramadol exerts a seizurogenic effect on mice via an H(1) receptor activation-linked pathway possibly through an opioid receptor-dependent release of histamine from the mast cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.