ArticleJournal of molecular neuroscience : MN2010
Nerve growth factor-induced protection of brain capillary endothelial cells exposed to oxygen-glucose deprivation involves attenuation of Erk phosphorylation.
Article in Journal of molecular neuroscience : MN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Nerve growth factor regulates endothelial cell survival and pathological retinal angiogenesis.Journal of cellular and molecular medicine · 2019Article
- Therapeutic Effect of Vinorine on Sciatic Nerve Injured Rat.Neurochemical research · 2018Article
- Apoptotic cell characteristics of rat brain microvascular endothelia induced by different degrees of hypoperfusion.International journal of clinical and experimental pathology · 2017Article
- Interferon gamma induces protective non-canonical signaling pathways in primary neurons.Journal of neurochemistry · 2015Article
- Shear stress inhibits apoptosis of ischemic brain microvascular endothelial cells.International journal of molecular sciences · 2013Article
- Control of arthritis pain with anti-nerve-growth factor: risk and benefit.Current rheumatology reports · 2012Review
- Multimodal neuroprotection induced by PACAP38 in oxygen-glucose deprivation and middle cerebral artery occlusion stroke models.Journal of molecular neuroscience : MN · 2012Article
- Therapeutic effect of nerve growth factor on cerebral infarction in dogs using the hemisphere anomalous volume ratio of diffusion-weighted magnetic resonance imaging.Neural regeneration research · 2012Article
- Breast cancer-induced bone remodeling, skeletal pain, and sprouting of sensory nerve fibers.The journal of pain · 2011Article
- Angiostatic effects of K252a, a Trk inhibitor, in murine brain capillary endothelial cells.Molecular and cellular biochemistry · 2010Article
- Nerve growth factor promotes cardiac repair following myocardial infarction.Circulation research · 2010Article
- Lettuce glycoside B ameliorates cerebral ischemia reperfusion injury by increasing nerve growth factor and neurotrophin-3 expression of cerebral cortex in rats.Indian journal of pharmacologyArticle
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Nerve growth factor (NGF) was recently characterized as an angiogenic factor inducing proliferation, migration, and capillary sprouting in endothelial cells (ECs) of different vascular beds. While NGF neuroprotective effects on neurons were described, its survival-inducing effects on brain capillary ECs were not yet addressed. Using a model of oxygen-glucose deprivation (OGD) followed by reoxygenation, we demonstrated that NGF conferred protection in brain capillary ECs. These cells express TrkA and p75(NTR) receptors and respond to NGF by stimulation of Erk1/2 phosphorylation and stimulation of proliferation and migration. The NGF protective effect was dose-dependent, inhibited by NGF/TrkA antagonist, K252a, and required presence of NGF during both OGD and reoxygenation phases while the major protective effect was related to decreased cell death during the reoxygenation phase. A causal relationship was found between NGF-induced protection and attenuation of OGD-induced Erk1/2 phosphorylation, supporting the death-promoting role of insult-induced Erk1/2 phosphorylation in the brain capillary ECs. These results emphasize the importance of NGF in the process of EC survival in response to ischemic injury and suggest fine-tuning regulation of Erk1/2 phosphorylation, extending the neuroprotective impact of NGF from sympathetic neuroendocrine cells to brain capillary ECs as the other element in the neurovascular tandem.
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