Trial reportPsychopharmacology2010
Acute dopamine and/or serotonin depletion does not modulate mismatch negativity (MMN) in healthy human participants.
Trial report in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 63 citations in OpenAlex.
- Trial
- Oscillatory underpinnings of mismatch negativity and their relationship with cognitive function in patients with schizophrenia.PloS one · 2013Trial
- Glutamatergic modulation of auditory information processing in the human brain.Biological psychiatry · 2012Trial
- Mismatch negativity encoding of prediction errors predicts S-ketamine-induced cognitive impairments.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Trial
- Inhibition of cerebral type 1 cannabinoid receptors is associated with impaired auditory mismatch negativity generation in the ketamine model of schizophrenia.Psychopharmacology · 2011Trial
- Pre-attentive processing in children with early and continuously-treated PKU. Effects of concurrent Phe level and lifetime dietary control.Journal of inherited metabolic disease · 2011Trial
- Dopamine in the Nucleus Accumbens Signals Salience of Auditory Deviance.The European journal of neuroscience · 2026Article
- Model-Based Approaches to Investigating Mismatch Responses in Schizophrenia.Clinical EEG and neuroscience · 2025Review
- Effect of antipsychotic on mismatch negativity amplitude and evoked theta power in drug-naïve patients with schizophrenia.BMC psychiatry · 2024Article
- The Use of Event-Related Potentials in the Study of Schizophrenia: An Overview.Advances in neurobiology · 2024Review
- A Predictive Coding Framework for Understanding Major Depression.Frontiers in human neuroscience · 2022Review
- The dopamine D2 agonist quinpirole impairs frontal mismatch responses to sound frequency deviations in freely moving rats.Neuropsychopharmacology reports · 2021Article
- Mismatch Negativity and Loudness Dependence of Auditory Evoked Potentials among Patients with Major Depressive Disorder, Bipolar II Disorder, and Bipolar I Disorder.Brain sciences · 2020Article
- Targeting Serotonin 5-HTCNS drugs · 2020Review
- The effects of methylphenidate on cerebral responses to conflict anticipation and unsigned prediction error in a stop-signal task.Journal of psychopharmacology (Oxford, England) · 2016Article
- Auditory mismatch impairments are characterized by core neural dysfunctions in schizophrenia.Brain : a journal of neurology · 2015Article
- Sensory processing dysfunction in the personal experience and neuronal machinery of schizophrenia.The American journal of psychiatry · 2015Review
- Mismatch negativity of sad syllables is absent in patients with major depressive disorder.PloS one · 2014Article
- Mismatch negativity: translating the potential.Frontiers in psychiatry · 2013Review
- Reorganisation of brain networks in frontotemporal dementia and progressive supranuclear palsy.NeuroImage. Clinical · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleSchizophrenia is commonly associated with impairments in pre-attentive change detection, as represented by reduced mismatch negativity (MMN). While the neurochemical basis of MMN has been linked to N-methyl-D: -aspartic acid (NMDA) receptor function, the roles of the dopaminergic and/or the serotonergic systems are not fully explored in humans.
objectivesThe aim of the present study was to investigate the effects of acutely depleting dopamine (DA) and serotonin (5-hydroxytryptamine, 5-HT) alone or simultaneously by depleting their amino acid precursors on MMN in healthy participants.
methodsSixteen healthy male subjects participated in a double-blind, placebo-controlled, cross-over design in which each subject's duration MMN was assessed under four acute treatment conditions separated by a 5-day washout period: balanced amino acid control (no depletion), tyrosine/phenylalanine depletion (to reduce DA neurotransmission), tryptophan depletion (to reduce 5-HT neurotransmission) and tryptophan/tyrosine/phenylalanine depletion (to reduce DA and 5-HT neurotransmission simultaneously).
resultsAcute depletion of either DA and 5-HT alone or simultaneously had no effect on MMN.
conclusionsThese findings suggest that modulation of the dopaminergic and serotonergic systems acutely does not lead to changes in MMN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.