ArticleMolecular vision2009
Prevention of selenite-induced cataractogenesis by rutin in Wistar rats.
Article in Molecular vision, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Perspectives of traditional herbal medicines in treating retinitis pigmentosa.Frontiers in medicine · 2024Article
- Antioxidant Nutraceutical Strategies in the Prevention of Oxidative Stress Related Eye Diseases.Nutrients · 2023Review
- Natural Antioxidant Activities of Plants in Preventing Cataractogenesis.Antioxidants (Basel, Switzerland) · 2022Review
- Application Potential of Plant-Derived Medicines in Prevention and Treatment of Platinum-Induced Peripheral Neurotoxicity.Frontiers in pharmacology · 2021Review
- Rutin Improves Bone Histomorphometric Values by Reduction of Osteoclastic Activity in Osteoporosis Mouse Model Induced by Bilateral Ovariectomy.Journal of Korean Neurosurgical Society · 2020Article
- Current Trends in the Pharmacotherapy of Cataracts.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Coffee brew intake can prevent the reduction of lens glutathione and ascorbic acid levels in HFD-fed animals.Experimental and therapeutic medicine · 2019Article
- Neuro-protective effect of rutin against Cisplatin-induced neurotoxic rat model.BMC complementary and alternative medicine · 2017Article
- Prevention and reversal of selenite-induced cataracts by N-acetylcysteine amide in Wistar rats.BMC ophthalmology · 2017Article
- The Pharmacological Potential of Rutin.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2017Review
- Rutin Inhibits Neuroinflammation and Provides Neuroprotection in an Experimental Rat Model of Subarachnoid Hemorrhage, Possibly Through Suppressing the RAGE-NF-κB Inflammatory Signaling Pathway.Neurochemical research · 2016Article
- Regulatory effect of chrysin on expression of lenticular calcium transporters, calpains, and apoptotic-cascade components in selenite-induced cataract.Molecular vision · 2016Article
- Flavonoid intake and the risk of age-related cataract in China's Heilongjiang Province.Food & nutrition research · 2015Article
- Grape seed extract and zinc containing nutritional food supplement prevents onset and progression of age-related cataract in wistar rats.The journal of nutrition, health & aging · 2014Article
- Plants used in the management of diabetic complications.Indian journal of pharmaceutical sciences · 2014Review
- Rutin ameliorates free radical mediated cataract by enhancing the chaperone activity of α-crystallin.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2013Article
- Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract.Interdisciplinary toxicology · 2011Article
- Amelioration of selenite toxicity and cataractogenesis in cultured rat lenses by Vitex negundo.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2011Article
- Different experimental approaches in modelling cataractogenesis: An overview of selenite-induced nuclear cataract in rats.Interdisciplinary toxicology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate whether rutin retards selenite-induced cataractogenesis in Wistar rat pups.
methodsOn postpartum day ten, Group I rat pups received an intraperitoneal injection of saline. Group II and III rat pups received a subcutaneous injection of sodium selenite. Group III also received an intraperitoneal injection of rutin once daily on postpartum days 9-14. Both eyes of each pup were examined from day 16 up to postpartum day 30. After sacrifice, extricated pup lenses were analyzed for mean activities of catalase, superoxide dismutase, glutathione peroxidase, glutathione S-transferase, and glutathione reductase. In addition, the mean concentrations of reduced glutathione (GSH) and of malondialdehyde were analyzed in samples of lenses and hemolysate.
resultsThere was dense lenticular opacification in all of Group II, minimal opacification in 33.3% of Group III, no opacification in 66.7% of Group III, and no opacification in Group I. Significantly lower mean activities of lenticular antioxidant enzymes were noted in Group II, compared to Group I and III. Significantly lower mean concentrations of GSH and higher mean concentrations of malondialdehyde were noted in samples of hemolysate and lens from Group II, compared to the values in Group I and III.
conclusionRutin prevents experimental selenite-induced cataractogenesis in rat pups, possibly by preventing depletion of antioxidant enzymes and of GSH, and by inhibiting lipid peroxidation.
Indexed as
Identifiers
20011628PMC2790477W2125456416What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.