Trial reportPloS one2009
Sexually transmitted infections among HIV-1-discordant couples.
Trial report in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00194519 (Phase III Randomized Placebo-Controlled Trial of HSV-2 Suppression to Prevent HIV Transmission Among HIV-Discordant Couples), which is not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase III Randomized Placebo-Controlled Trial of HSV-2 Suppression to Prevent HIV Transmission Among HIV-Discordant Couples
Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- HERMITAGE--a randomized controlled trial to reduce sexually transmitted infections and HIV risk behaviors among HIV-infected Russian drinkers.Addiction (Abingdon, England) · 2015Trial
- Multi-Target Molecular Detection of Sexually Transmitted Infections in Women Living with HIV in Northeastern Brazil.Tropical medicine and infectious disease · 2025Article
- A High-throughput Bead-based Affinity Assay Enables Analysis of Genital Protein Signatures in Women At Risk of HIV Infection.Molecular & cellular proteomics : MCP · 2019Article
- Demographic and behavioural risk factors associated withBMJ open · 2017Article
- Do as we say, not as we do: experiences of unprotected intercourse reported by members of the Society of Family Planning.Contraception · 2015Article
- Sexual Behavior and Risk Practices of HIV Positive and HIV Negative Rwandan Women.AIDS and behavior · 2015Article
- Clinical use of vaginal or rectally applied microbicides in patients suffering from HIV/AIDS.HIV/AIDS (Auckland, N.Z.) · 2013Review
- The impact of Fogarty International Center research training programs on public health policy and program development in Kenya and Uganda.BMC public health · 2013Article
- Sexually transmitted infections among HIV-infected heavy drinkers in St Petersburg, Russia.International journal of STD & AIDS · 2012Article
- Fluorometric high-throughput assay for measuring chlamydial neutralizing antibody.Clinical and vaccine immunology : CVI · 2012Article
- Safety and pharmacokinetics of intravaginal rings delivering tenofovir in pig-tailed macaques.Antimicrobial agents and chemotherapy · 2012Article
- Chlamydia and Gonorrhea Infections in HIV-positive Women in Urban Lusaka, Zambia.Journal of global infectious diseases · 2012Article
- Simultaneous delivery of tenofovir and acyclovir via an intravaginal ring.Antimicrobial agents and chemotherapy · 2012Article
- Microbicides: a new hope for HIV prevention.The Indian journal of medical research · 2011Review
- A rabbit vaginal cell-derived antimicrobial peptide, RVFHbαP, blocks lipopolysaccharide-mediated inflammation in human vaginal cells in vitro.Clinical and vaccine immunology : CVI · 2011Article
- HIV incidence and risk factors for acquisition in HIV discordant couples in Masaka, Uganda: an HIV vaccine preparedness study.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionMore new HIV-1 infections occur within stable HIV-1-discordant couples than in any other group in Africa, and sexually transmitted infections (STIs) may increase transmission risk among discordant couples, accounting for a large proportion of new HIV-1 infections. Understanding correlates of STIs among discordant couples will aid in optimizing interventions to prevent HIV-1 transmission in these couples.
methodsHIV-1-discordant couples in which HIV-1-infected partners were HSV-2-seropositive were tested for syphilis, chlamydia, gonorrhea, and trichomoniasis, and HIV-1-uninfected partners were tested for HSV-2. We assessed sociodemographic, behavioral, and biological correlates of a current STI.
resultsOf 416 couples enrolled, 16% were affected by a treatable STI, and among these both partners were infected in 17% of couples. A treatable STI was found in 46 (11%) females and 30 (7%) males. The most prevalent infections were trichomoniasis (5.9%) and syphilis (2.6%). Participants were 5.9-fold more likely to have an STI if their partner had an STI (P<0.01), and STIs were more common among those reporting any unprotected sex (OR = 2.43; P<0.01) and those with low education (OR = 3.00; P<0.01). Among HIV-1-uninfected participants with an HSV-2-seropositive partner, females were significantly more likely to be HSV-2-seropositive than males (78% versus 50%, P<0.01).
conclusionsTreatable STIs were common among HIV-1-discordant couples and the majority of couples affected by an STI were discordant for the STI, with relatively high HSV-2 discordance. Awareness of STI correlates and treatment of both partners may reduce HIV-1 transmission.
trial registrationClinicalTrials.gov NCT00194519.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.