ArticlePloS one2009
RNA-interference knockdown of Drosophila pigment dispersing factor in neuronal subsets: the anatomical basis of a neuropeptide's circadian functions.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- Hsp90 buffers behavioral variability by regulating Pdf transcription in clock neurons of Drosophila melanogaster.PLoS genetics · 2026Article
- Drosophila Pyruvate Kinase Links Metabolic State with Circadian Output via TARANIS and PDF.Research square · 2025Article
- Drosophila Pyruvate Kinase Links Metabolic State with Circadian Output via TARANIS and PDF.bioRxiv : the preprint server for biology · 2025Article
- Mutual coupling of neurons in the circadian master clock: What we can learn from fruit flies.Neurobiology of sleep and circadian rhythms · 2025Article
- Article
- Sex- and strain-dependent effects of ageing on sleep and activity patterns in Drosophila.PloS one · 2024Article
- Article
- Dissecting neuron-specific functions of circadian genes using modified cell-specific CRISPR approaches.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Mating disrupts morning anticipation in Drosophila melanogaster females.PLoS genetics · 2022Article
- Connectomic analysis of theeLife · 2022Article
- Hsp40 overexpression in pacemaker neurons delays circadian dysfunction in a Drosophila model of Huntington's disease.Disease models & mechanisms · 2022Article
- Regulation of PDF receptor signaling controlling daily locomotor rhythms in Drosophila.PLoS genetics · 2022Article
- Modulation of Metabolic Hormone Signaling via a Circadian Hormone and Biogenic Amine inInternational journal of molecular sciences · 2022Article
- Under warm ambient conditions, Drosophila melanogaster suppresses nighttime activity via the neuropeptide pigment dispersing factor.Genes, brain, and behavior · 2022Article
- The microtubule-associated protein Tau suppresses the axonal distribution of PDF neuropeptide and mitochondria in circadian clock neurons.Human molecular genetics · 2022Article
- Pigment Dispersing Factor Is a Circadian Clock Output and Regulates Photoperiodic Response in the Linden Bug,Frontiers in physiology · 2022Article
- Article
- Dorsal clock neurons iniScience · 2021Article
- Integration of Circadian Clock Information in theJournal of biological rhythms · 2021Review
- Daily rewiring of a neural circuit generates a predictive model of environmental light.Science advances · 2021Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
Funding
Abstract
backgroundIn animals, neuropeptide signaling is an important component of circadian timekeeping. The neuropeptide pigment dispersing factor (PDF) is required for several aspects of circadian activity rhythms in Drosophila. METHODOLOGY/PRINCIPAL
findingsHere we investigate the anatomical basis for PDF's various circadian functions by targeted PDF RNA-interference in specific classes of Drosophila neuron. We demonstrate that PDF is required in the ventro-lateral neurons (vLNs) of the central brain and not in the abdominal ganglion for normal activity rhythms. Differential knockdown of PDF in the large or small vLNs indicates that PDF from the small vLNs is likely responsible for the maintenance of free-running activity rhythms and that PDF is not required in the large vLNs for normal behavior. PDF's role in setting the period of free-running activity rhythms and the proper timing of evening activity under light:dark cycles emanates from both subtypes of vLN, since PDF in either class of vLN was sufficient for these aspects of behavior. CONCLUSIONS/SIGNIFICANCE: These results reveal the neuroanatomical basis PDF's various circadian functions and refine our understanding of the clock neuron circuitry of Drosophila.
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