ArticleClinics in colon and rectal surgery2008
Perineal wound complications after abdominoperineal resection.
Article in Clinics in colon and rectal surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 9 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Negative-pressure wound therapy for perineal wound complications after abdominoperineal resection/extralevator APR: Systematic review and meta-analysis.Techniques in coloproctology · 2026Pooled it
- Effect of negative pressure wound therapy on surgical wound outcomes in colorectal cancer surgery patients: a systematic review and meta-analysis.BMC surgery · 2026Pooled it
- Surgical outcomes in pelvic reconstruction using robot-assisted rectus abdominis muscle flaps: a systematic review.International journal of colorectal disease · 2026Pooled it
- Evaluating negative-pressure wound therapy after abdominoperineal resection: a systematic review of efficacy and technical variability.Techniques in coloproctology · 2025Pooled it
- Primary closure versus vertical rectus abdominis myocutaneous (VRAM) flap closure of perineal wound following abdominoperineal resection-a systematic review and meta-analysis.Irish journal of medical science · 2024Pooled it
- Meta-analysis of biological mesh reconstruction versus primary perineal closure after abdominoperineal excision of rectal cancer.International journal of colorectal disease · 2021Pooled it
- The role of perineal application of prophylactic negative-pressure wound therapy for prevention of wound-related complications after abdomino-perineal resection: a systematic review.International journal of colorectal disease · 2021Pooled it
- The application of incisional negative pressure wound therapy for perineal wounds: A systematic review.International wound journal · 2018Pooled it
- Local Application of Gentamicin in the Prophylaxis of Perineal Wound Infection After Abdominoperineal Resection: A Systematic Review.World journal of surgery · 2015Pooled it
- Sphincter preservation in patients with low rectal cancer: striking the right oncological balance.Discover oncology · 2021Trial
- A new surgical approach of direct perineal wound full-thick closure for perineal wound of abdominoperineal resection for rectal carcinoma: A prospective cohort trial.International wound journal · 2020Trial
- Perineal infection and risk factors following extralevator abdominoperineal excision and reconstruction with an absorbable synthetic prosthesis.Updates in surgery · 2026Observational
- Flap reconstruction versus primary perineal closure after abdominoperineal resection: a systematic review and meta-analysis.Updates in surgery · 2026Article
- Oblique Rectus Abdominis Myocutaneous Versus Anterolateral Thigh-Vastus Lateralis Flap for Perineal Reconstruction: A Retrospective Comparative Study.Plastic and reconstructive surgery. Global open · 2026Article
- Comparison of morbidity and mortality of abdominoperineal resection vs low anterior resection in rectal cancer.Journal of medicine and life · 2026Article
- Effectiveness and outcome of gracilis muscle flap reconstruction following perineal surgery: a retrospective single-center cohort study.Annals of medicine and surgery (2012) · 2026Article
- Preoperative Radiotherapy as a Major Risk Factor for Pelvic Abscess after Abdominoperineal Resection and Total Pelvic Exenteration: A Retrospective Study.Journal of the anus, rectum and colon · 2026Article
- A Case of a Longstanding Perianal Lesion Presenting as Advanced Squamous Cell Carcinoma of the Anus.Cureus · 2025Article
- Reconstruction of the Vulva and Perineum-Comparison of Surgical Methods.Journal of clinical medicine · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perineal wound complications following abdominoperineal resection (APR) is a common occurrence. Risk factors such as operative technique, preoperative radiation therapy, and indication for surgery (i.e., rectal cancer, anal cancer, or inflammatory bowel disease [IBD]) are strong predictors of these complications. Patient risk factors include diabetes, obesity, and smoking. Intraoperative perineal wound management has evolved from open wound packing to primary closure with closed suctioned transabdominal pelvic drains. Wide excision is used to gain local control in cancer patients, and coupled with the increased use of pelvic radiation therapy, we have experienced increased challenges with primary closure of the perineal wound. Tissue transfer techniques such as omental pedicle flaps, and vertical rectus abdominis and gracilis muscle or myocutaneous flaps are being used to reconstruct large perineal defects and decrease the incidence of perineal wound complications. Wound failure is frequently managed by wet to dry dressing changes, but can result in prolonged hospital stay, hospital readmission, home nursing wound care needs, and the expenditure of significant medical costs. Adjuvant therapies to conservative wound care have been suggested, but evidence is still lacking. The use of the vacuum-assisted closure device has shown promise in chronic soft tissue wounds; however, experience is lacking, and is likely due to the difficulty in application techniques.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.