ArticlePLoS computational biology2009
Cortical gamma rhythms modulate NMDAR-mediated spike timing dependent plasticity in a biophysical model.
Article in PLoS computational biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Applications and potential mechanisms of transcranial magnetic stimulation in autism spectrum disorders.Journal of translational medicine · 2026Review
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- A genetic algorithm for self-supervised models of oscillatory neurodynamics.bioRxiv : the preprint server for biology · 2025Article
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- Basolateral amygdala oscillations enable fear learning in a biophysical model.bioRxiv : the preprint server for biology · 2024Article
- Neural oscillations and memory: unraveling the mechanisms of anesthesia-induced amnesia.Frontiers in neuroscience · 2024Review
- Dynamic Changes in Local Activity and Network Interactions among the Anterior Cingulate, Amygdala, and Cerebellum during Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Review
- Tuning Neural Synchronization: The Role of Variable Oscillation Frequencies in Neural Circuits.Frontiers in systems neuroscience · 2022Review
- Gamma Oscillations Facilitate Effective Learning in Excitatory-Inhibitory Balanced Neural Circuits.Neural plasticity · 2021Article
- Cortical recruitment determines learning dynamics and strategy.Nature communications · 2019Article
- Rhythmogenesis evolves as a consequence of long-term plasticity of inhibitory synapses.Scientific reports · 2018Article
- Sleep regulation of the distribution of cortical firing rates.Current opinion in neurobiology · 2017Review
- Common oscillatory mechanisms across multiple memory systems.NPJ science of learning · 2017Article
- GABAB receptor-mediated, layer-specific synaptic plasticity reorganizes gamma-frequency neocortical response to stimulation.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Oscillations via Spike-Timing Dependent Plasticity in a Feed-Forward Model.PLoS computational biology · 2016Article
- Oscillation, Conduction Delays, and Learning Cooperate to Establish Neural Competition in Recurrent Networks.PloS one · 2016Article
- Rodent auditory perception: Critical band limitations and plasticity.Neuroscience · 2015Review
- Brain rhythms connect impaired inhibition to altered cognition in schizophrenia.Biological psychiatry · 2015Review
- Input-dependent frequency modulation of cortical gamma oscillations shapes spatial synchronization and enables phase coding.PLoS computational biology · 2015Article
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3 authors.
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Abstract
Spike timing dependent plasticity (STDP) has been observed experimentally in vitro and is a widely studied neural algorithm for synaptic modification. While the functional role of STDP has been investigated extensively, the effect of rhythms on the precise timing of STDP has not been characterized as well. We use a simplified biophysical model of a cortical network that generates pyramidal interneuronal gamma rhythms (PING). Plasticity via STDP is investigated at the excitatory pyramidal cell synapse from a gamma frequency (30-90 Hz) input independent of the network gamma rhythm. The input may represent a corticocortical or an information-specific thalamocortical connection. This synapse is mediated by N-methyl-D-aspartate receptor mediated (NMDAR) currents. For distinct network and input frequencies, the model shows robust frequency regimes of potentiation and depression, providing a mechanism by which responses to certain inputs can potentiate while responses to other inputs depress. For potentiating regimes, the model suggests an optimal amount and duration of plasticity that can occur, which depends on the time course for the decay of the postsynaptic NMDAR current. Prolonging the duration of the input beyond this optimal time results in depression. Inserting pauses in the input can increase the total potentiation. The optimal pause length corresponds to the decay time of the NMDAR current. Thus, STDP in this model provides a mechanism for potentiation and depression depending on input frequency and suggests that the slow NMDAR current decay helps to regulate the optimal amplitude and duration of the plasticity. The optimal pause length is comparable to the time scale of the negative phase of a modulatory theta rhythm, which may pause gamma rhythm spiking. Our pause results may suggest a novel role for this theta rhythm in plasticity. Finally, we discuss our results in the context of auditory thalamocortical plasticity.
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