ArticleMolecular vision2009
Lack of association between toll-like receptor 4 gene polymorphisms and sarcoidosis-related uveitis in Japan.
Article in Molecular vision, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Noninfectious uveitis in the Asia-Pacific region.Eye (London, England) · 2019Review
- Association of genetic variants inMolecular vision · 2018Article
- Induction of Pulmonary Granuloma Formation by Propionibacterium acnes Is Regulated by MyD88 and Nox2.American journal of respiratory cell and molecular biology · 2017Article
- Sarcoidosis vs. Sarcoid-like reactions: The Two Sides of the same Coin?Wiener medizinische Wochenschrift (1946) · 2014Review
- The association of Toll-like receptor 4 gene polymorphisms with the development of emphysema in Japanese subjects: a case control study.BMC research notes · 2012Article
- Lack of association between IL10 polymorphisms and sarcoidosis in Japanese patients.Molecular vision · 2012Article
- Toll-like receptor 2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population.Molecular vision · 2011Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeToll-like receptors (TLRs) are pattern-recognition receptors that play an important role in innate and adaptive immune responses to microbial pathogens. Among TLRs, TLR4 recognizes lipopolysaccharides of Gram-negative bacteria. Genetic polymorphisms within the TLR4 gene have been reported to be associated with various inflammatory diseases; therefore, TLR4 appears to be a susceptibility gene for sarcoidosis. Although sarcoidosis has various clinical manifestations, its association with uveitis is more common in Japan than in other countries. The aim of this study was to investigate whether TLR4 polymorphisms were associated with sarcoidosis-related uveitis in a Japanese population.
methodsTwo hundred twenty-three patients with sarcoidosis and 206 healthy control subjects were recruited at seven sites in Japan. Eight single-nucleotide polymorphisms (SNPs) in TLR4 were genotyped with a TaqMan assay, and allelic and phenotypic diversity were assessed in affected and control subjects.
resultsWe found no association with susceptibility to sarcoid-related uveitis for any of the SNPs analyzed. Strong linkage disequilibrium was observed among all the SNPs analyzed (D'>/=0.78), which were located in one haplotype block.
conclusionTLR4 polymorphisms do not play an important role in the development of uveitis in Japanese patients with sarcoidosis.
Indexed as
Identifiers
20011079PMC2791040W2121617014What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.