ArticleJournal of exposure science & environmental epidemiology
Internal exposure to pollutants and sex hormone levels in Flemish male adolescents in a cross-sectional study: associations and dose-response relationships.
Article in Journal of exposure science & environmental epidemiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 42 citations in OpenAlex.
- The Association of Cadmium Exposure and Anthropometrics in School-Age Children: A Longitudinal Study.Biological trace element research · 2026Article
- Investigating how blood cadmium levels influence cardiovascular health scores across sexes and dose responses.Frontiers in public health · 2024Article
- Associations between blood cadmium and endocrine features related to PCOS-phenotypes in healthy women of reproductive age: a prospective cohort study.Environmental health : a global access science source · 2021Article
- Prenatal Cadmium Exposure Is Negatively Associated With Adiposity in Girls Not Boys During Adolescence.Frontiers in public health · 2019Article
- Risk for animal and human health related to the presence of dioxins and dioxin-like PCBs in feed and food.EFSA journal. European Food Safety Authority · 2018Article
- Endocrine actions of pesticides measured in the Flemish environment and health studies (FLEHS I and II).Environmental science and pollution research international · 2015Article
- Changes in persistent organic pollutant levels from adolescence to young adulthood.Environmental research · 2015Article
- Endocrine disruption of the epigenome: a breast cancer link.Endocrine-related cancer · 2014Review
- Relationships of polychlorinated biphenyls and dichlorodiphenyldichloroethylene (p,p'-DDE) with testosterone levels in adolescent males.Environmental health perspectives · 2014Article
- Environmental exposure to metals and children's growth to age 5 years: a prospective cohort study.American journal of epidemiology · 2013Article
- Serum concentrations of p, p'-DDE, HCB, PCBs and reproductive hormones among men of reproductive age.Reproductive toxicology (Elmsford, N.Y.) · 2012Article
- Endocrine-disrupting chemicals: associated disorders and mechanisms of action.Journal of environmental and public health · 2012Review
- Prevalence of at-risk genotypes for genotoxic effects decreases with age in a randomly selected population in Flanders: a cross sectional study.Environmental health : a global access science source · 2011Article
- Internal exposure to pollutants and sexual maturation in Flemish adolescents.Journal of exposure science & environmental epidemiologyArticle
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flanders is densely populated with much industry and intensive farming. Hormonal status of 14- to 15-year-old male adolescents was studied in relation to internal exposure to pollutants. A total of 887 participants were selected as a random sample of the adolescents residing in the study areas. Confounding factors and significant covariates were taken into account. Serum levels of testosterone, free testosterone and estradiol, and the aromatase index showed significant positive associations with serum levels of marker polychlorobiphenyls (sum of PCBs 138, 153, and 180) and of hexachlorobenzene (HCB) and a negative association with urinary cadmium concentration. Serum levels of estradiol also showed a positive association with serum levels of dichlorodiphenyldichloroethylene (DDE). A doubling of serum concentrations of marker PCBs and HCB and of urinary concentration of cadmium were, respectively, associated with an increase of 16.4% (P<0.00001) and 16.6% (P<0.001) and a decrease of 9.6% (P<0.001) in serum testosterone concentration. Similar findings were made after additional adjustment for concurrent exposures. Associations between biological effects and internal exposures were, in terms of the regression coefficient, often stronger at exposures below the median. Environmental exposures to pollutants resulting in "normal" levels of internal exposure were associated with quite substantial differences in hormone concentrations.
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