ArticleNature cell biology2010
Maintenance of a constitutive heterochromatin domain in vertebrates by a Dicer-dependent mechanism.
Article in Nature cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Small Interfering RNAs Targeting a Chromatin-Associated RNA Induce Its Transcriptional Silencing in Human Cells.Molecular and cellular biology · 2022Article
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- CyclinD1 inhibits dicer and crucial miRNA expression by chromatin modification to promote the progression of intrahepatic cholangiocarcinoma.Journal of experimental & clinical cancer research : CR · 2019Article
- Soluble inflammatory mediators induce transcriptional re-organization that is independent of dna methylation changes in cultured human chorionic villous trophoblasts.Journal of reproductive immunology · 2018Article
- The effect of epigenetic modifications on the secondary structures and possible binding positions of the N-terminal tail of histone H3 in the nucleosome: a computational study.Journal of molecular modeling · 2017Article
- Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression.Current genomics · 2017Review
- Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.Cell death & disease · 2017Article
- Article
- Human Argonaute 2 Is Tethered to Ribosomal RNA through MicroRNA Interactions.The Journal of biological chemistry · 2016Article
- Article
- DICER/AGO-dependent epigenetic silencing of D4Z4 repeats enhanced by exogenous siRNA suggests mechanisms and therapies for FSHD.Human molecular genetics · 2015Article
- Post-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virus.World journal of virology · 2015Review
- Argonaute 2 Binds Directly to tRNA Genes and Promotes Gene Repression in cis.Molecular and cellular biology · 2015Article
- Non-Coding RNA: Sequence-Specific Guide for Chromatin Modification and DNA Damage Signaling.Frontiers in genetics · 2015Review
- Physical chemistry of nucleic acids and their complexes.Biopolymers · 2013Article
- Argonaute 2 sustains the gene expression program driving human monocytic differentiation of acute myeloid leukemia cells.Cell death & disease · 2013Article
- Chromatin structure outside and inside the nucleus.Biopolymers · 2013Article
- Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells.Nature structural & molecular biology · 2012Article
- Transcriptional targeting by microRNA-polycomb complexes: a novel route in cell fate determination.Cell cycle (Georgetown, Tex.) · 2012Article
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Authors and funding
3 authors.
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Abstract
The 16 kilobase (kb) heterochromatin domain between the chicken beta-globin locus and the folate receptor gene is used here to study the roles of RNA-dependent mechanisms and histone modifications in the maintenance of a constitutive heterochromatic structure. Inhibition of histone deacetylase (HDAC) activity is shown to both increase intergenic transcription and render the heterochromatin more accessible to MspI digestion. We show that short interfering RNA (siRNA)-mediated downregulation of the enzyme Dicer has similar effects: histone acetylation is increased, transcript levels rise and the compact chromatin structure becomes more accessible to restriction endonucleases. We also show that the chicken Argonaute 2 homologue binds the 16 kb region in a Dicer-dependent manner and is necessary for a condensed chromatin structure. Heterochromatic domains of this kind, which are widely distributed in vertebrate genomes, thus seem to be maintained in their condensed form by highly conserved mechanisms.
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