ArticleEMBO reports2010
RNA-directed DNA methylation and plant development require an IWR1-type transcription factor.
Article in EMBO reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 73 citations in OpenAlex.
- Reproductive developmental transcriptome analysis of Tripidium ravennae (Poaceae).BMC genomics · 2021Article
- A Role for PICKLE in the Regulation of Cold and Salt Stress Tolerance in Arabidopsis.Frontiers in plant science · 2019Article
- RNA-mediated transgenerational inheritance in ciliates and plants.Chromosoma · 2018Review
- A Role for MINIYO and QUATRE-QUART2 in the Assembly of RNA Polymerases II, IV, and V in Arabidopsis.The Plant cell · 2018Article
- The developmental regulator PKL is required to maintain correct DNA methylation patterns at RNA-directed DNA methylation loci.Genome biology · 2017Article
- RDM4 modulates cold stress resistance in Arabidopsis partially through the CBF-mediated pathway.The New phytologist · 2016Article
- RNA-directed DNA methylation in plants.Plant cell reports · 2015Article
- RNA Pol IV and V in gene silencing: Rebel polymerases evolving away from Pol II's rules.Current opinion in plant biology · 2015Review
- GFP Loss-of-Function Mutations in Arabidopsis thaliana.G3 (Bethesda, Md.) · 2015Article
- An Rtf2 Domain-Containing Protein Influences Pre-mRNA Splicing and Is Essential for Embryonic Development in Arabidopsis thaliana.Genetics · 2015Article
- siRNA-directed DNA Methylation in Plants.Current genomics · 2015Article
- slc7a6os gene plays a critical role in defined areas of the developing CNS in zebrafish.PloS one · 2015Article
- Functional diversification of maize RNA polymerase IV and V subtypes via alternative catalytic subunits.Cell reports · 2014Article
- RNA-directed DNA methylation: an epigenetic pathway of increasing complexity.Nature reviews. Genetics · 2014Review
- Noncoding RNAs and DNA Methylation in Plants.National science review · 2014Article
- Connecting the dots of RNA-directed DNA methylation in Arabidopsis thaliana.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2014Review
- The SET domain proteins SUVH2 and SUVH9 are required for Pol V occupancy at RNA-directed DNA methylation loci.PLoS genetics · 2014Article
- Roles, and establishment, maintenance and erasing of the epigenetic cytosine methylation marks in plants.Journal of genetics · 2013Review
- siRNA-mediated DNA methylation and H3K9 dimethylation in plants.Protein & cell · 2013Review
- DTF1 is a core component of RNA-directed DNA methylation and may assist in the recruitment of Pol IV.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA-directed DNA methylation (RdDM) in plants requires two RNA polymerase (Pol) II-related RNA polymerases, namely Pol IV and Pol V. A genetic screen designed to reveal factors that are important for RdDM in a developmental context in Arabidopsis identified DEFECTIVE IN MERISTEM SILENCING 4 (DMS4). Unlike other mutants defective in RdDM, dms4 mutants have a pleiotropic developmental phenotype. The DMS4 protein is similar to yeast IWR1 (interacts with RNA polymerase II), a conserved putative transcription factor that interacts with Pol II subunits. The DMS4 complementary DNA partly complements the K1 killer toxin hypersensitivity of a yeast iwr1 mutant, suggesting some functional conservation. In the transgenic system studied, mutations in DMS4 directly or indirectly affect Pol IV-dependent secondary short interfering RNAs, Pol V-mediated RdDM, Pol V-dependent synthesis of intergenic non-coding RNA and expression of many Pol II-driven genes. These data suggest that DMS4 might be a regulatory factor for several RNA polymerases, thus explaining its diverse roles in the plant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.