ArticleThe EMBO journal2010
Transduction of RNA-directed DNA methylation signals to repressive histone marks in Arabidopsis thaliana.
Article in The EMBO journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation.Nature communications · 2023Article
- The MOM1 complex recruits the RdDM machinery via MORC6 to establishbioRxiv : the preprint server for biology · 2023Article
- TheFrontiers in plant science · 2023Article
- The epiallelic potential of transposable elements and its evolutionary significance in plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Dynamics and function of DNA methylation in plants.Nature reviews. Molecular cell biology · 2018Review
- EAT1 transcription factor, a non-cell-autonomous regulator of pollen production, activates meiotic small RNA biogenesis in rice anther tapetum.PLoS genetics · 2018Article
- Exploring potential roles for the interaction of MOM1 with SUMO and the SUMO E3 ligase-like protein PIAL2 in transcriptional silencing.PloS one · 2018Article
- SUPPRESSOR OF FRIGIDA (SUF4) Supports Gamete Fusion via Regulating Arabidopsis EC1 Gene Expression.Plant physiology · 2017Article
- Parental epigenetic asymmetry of PRC2-mediated histone modifications in the Arabidopsis endosperm.The EMBO journal · 2016Article
- The SUMO E3 Ligase-Like Proteins PIAL1 and PIAL2 Interact with MOM1 and Form a Novel Complex Required for Transcriptional Silencing.The Plant cell · 2016Article
- HISTONE DEACETYLASE6 Controls Gene Expression Patterning and DNA Methylation-Independent Euchromatic Silencing.Plant physiology · 2015Article
- SUVR2 is involved in transcriptional gene silencing by associating with SNF2-related chromatin-remodeling proteins in Arabidopsis.Cell research · 2014Article
- Does the upstream region possessing MULE-like sequence in rice upregulate PsbS1 gene expression?PloS one · 2014Article
- RNA-directed DNA methylation regulates parental genomic imprinting at several loci in Arabidopsis.Development (Cambridge, England) · 2013Article
- DTF1 is a core component of RNA-directed DNA methylation and may assist in the recruitment of Pol IV.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The role of the Arabidopsis Exosome in siRNA-independent silencing of heterochromatic loci.PLoS genetics · 2013Article
- Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1.PLoS genetics · 2012Article
- Article
- An atypical component of RNA-directed DNA methylation machinery has both DNA methylation-dependent and -independent roles in locus-specific transcriptional gene silencing.Cell research · 2011Article
- Independent chromatin binding of ARGONAUTE4 and SPT5L/KTF1 mediates transcriptional gene silencing.PLoS genetics · 2011Article
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13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA-directed modification of histones is essential for the maintenance of heterochromatin in higher eukaryotes. In plants, cytosine methylation is an additional factor regulating inactive chromatin, but the mechanisms regulating the coexistence of cytosine methylation and repressive histone modification remain obscure. In this study, we analysed the mechanism of gene silencing mediated by MORPHEUS' MOLECULE1 (MOM1) of Arabidopsis thaliana. Transcript profiling revealed that the majority of up-regulated loci in mom1 carry sequences related to transposons and homologous to the 24-nt siRNAs accumulated in wild-type plants that are the hallmarks of RNA-directed DNA methylation (RdDM). Analysis of a single-copy gene, SUPPRESSOR OF drm1 drm2 cmt3 (SDC), revealed that mom1 activates SDC with concomitant reduction of di-methylated histone H3 lysine 9 (H3K9me2) at the tandem repeats in the promoter region without changes in siRNA accumulation and cytosine methylation. The reduction of H3K9me2 is not observed in regions flanking the tandem repeats. The results suggest that MOM1 transduces RdDM signals to repressive histone modification in the core region of RdDM.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.