ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2010
Serotonin depletion hampers survival and proliferation in neurospheres derived from adult neural stem cells.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- A comprehensive overview of the biological foundations of ADHD.Bioscience reports · 2026Review
- Beyond neurotransmission: the roles of serotonylation in physiological and pathological processes.Cellular & molecular biology letters · 2026Review
- Psychosomatics at the threshold: cancer, mood disorders, and the mental pain of death - where precision medicine meets spirituality.Frontiers in psychiatry · 2026Article
- Review
- Cannabidiol Exerts Sedative and Hypnotic Effects in Normal and Insomnia Model Mice Through Activation of 5-HTNeurochemical research · 2024Article
- SERS detection of dopamine using metal-chelated Ag nanoshell.RSC advances · 2024Article
- Review
- Gut brain interaction theory reveals gut microbiota mediated neurogenesis and traditional Chinese medicine research strategies.Frontiers in cellular and infection microbiology · 2022Review
- Microbiota-Gut-Brain Axis Regulation of Adult Hippocampal Neurogenesis.Brain plasticity (Amsterdam, Netherlands) · 2022Review
- Constitutive Activity of Serotonin Receptor 6 Regulates Human Cerebral Organoids Formation and Depression-like Behaviors.Stem cell reports · 2021Article
- Trehalose as glucose surrogate in proliferation and cellular mobility of adult neural progenitor cells derived from mouse hippocampus.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- In vivo relationship between serotonin 1A receptor binding and gray matter volume in the healthy brain and in major depressive disorder.Brain structure & function · 2018Article
- Recent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative Diseases.Molecules (Basel, Switzerland) · 2016Review
- Control of adult neurogenesis by programmed cell death in the mammalian brain.Molecular brain · 2016Review
- 5-HT2 receptors mediate functional modulation of GABAa receptors and inhibitory synaptic transmissions in human iPS-derived neurons.Scientific reports · 2016Article
- Fluoxetine regulates neurogenesis in vitro through modulation of GSK-3β/β-catenin signaling.The international journal of neuropsychopharmacology · 2014Article
- Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin.Archives of biochemistry and biophysics · 2014Article
- Fluoxetine induces proliferation and inhibits differentiation of hypothalamic neuroprogenitor cells in vitro.PloS one · 2014Article
- Article
- Serotonin of mast cell origin contributes to hippocampal function.The European journal of neuroscience · 2012Article
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16 authors.
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Abstract
Serotonin (5-HT) and the serotonergic system have recently been indicated as modulators of adult hippocampal neurogenesis. In this study, we evaluated the role of 5-HT on the functional features in neurospheres derived from adult neural stem cells (ANSC). We cultured neurospheres derived from mouse hippocampus in serum-free medium containing epidermal (EGF) and type-2 fibroblast growth factor (FGF2). Under these conditions ANSC expressed both isoforms of tryptophane-hydroxylase (TPH) and produced 5-HT. Blocking TPH function by para-chlorophenylalanine (PCPA) reduced ANSC proliferation, which was rescued by exogenous 5-HT. 5-HT action on ANSC was mediated predominantly by the serotonin receptor subtype 5-HT1A and, to a lesser extent, through the 5-HT2C (receptor) subtype, as shown by selectively antagonizing these receptors. Finally, we documented a 5-HT-induced increase of ANSC migration activity. In summary, we demonstrated a powerful serotonergic impact on ANSC functional features, which was mainly mediated by 5-HT1A receptors.
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