ArticleThe Journal of trauma2009
Burns, inflammation, and intestinal injury: protective effects of an anti-inflammatory resuscitation strategy.
Article in The Journal of trauma, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Targeting the gut to prevent sepsis from a cutaneous burn.JCI insight · 2020Article
- Why Antibiotic Treatment Is Not Enough for Sepsis Resolution: an Evaluation in an Experimental Animal Model.Infection and immunity · 2017Article
- Reduction of venous pressure during the resection of liver metastases compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury.Clinics (Sao Paulo, Brazil) · 2017Article
- An oligodeoxynucleotide with AAAG repeats significantly attenuates burn-induced systemic inflammatory responses via inhibiting interferon regulatory factor 5 pathway.Molecular medicine (Cambridge, Mass.) · 2017Article
- Nrf2 plays a pivotal role in protection against burn trauma-induced intestinal injury and death.Oncotarget · 2016Article
- Intraluminal Flagellin Differentially Contributes to Gut Dysbiosis and Systemic Inflammation following Burn Injury.PloS one · 2016Article
- Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol.Alcohol (Fayetteville, N.Y.) · 2013Article
- Anti-IL-6 antibody treatment but not IL-6 knockout improves intestinal barrier function and reduces inflammation after binge ethanol exposure and burn injury.Shock (Augusta, Ga.) · 2013Article
- Enteric glia cells attenuate cytomix-induced intestinal epithelial barrier breakdown.PloS one · 2013Article
- Intravenous phage display identifies peptide sequences that target the burn-injured intestine.Peptides · 2012Article
- Period of irreversible therapeutic intervention during sepsis correlates with phase of innate immune dysfunction.The Journal of biological chemistry · 2012Article
- CPSI-121 pharmacologically prevents intestinal barrier dysfunction after cutaneous burn through a vagus nerve-dependent mechanism.The journal of trauma and acute care surgery · 2012Article
- Burn resuscitation.Scandinavian journal of trauma, resuscitation and emergency medicine · 2011Review
- Efferent vagal nerve stimulation attenuates acute lung injury following burn: The importance of the gut-lung axis.Surgery · 2011Article
- The hormone ghrelin prevents traumatic brain injury induced intestinal dysfunction.Journal of neurotrauma · 2010Article
- Therapeutic effect of bromelain and papain on intestinal injury induced by indomethacin in male rats.International journal of health sciencesArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIntestinal barrier breakdown after severe burn can lead to intestinal inflammation, which may act as the source of the systemic inflammatory response. In vitro intestinal cell studies have shown that mitogen-activated protein kinase (MAPK) signaling is an important modulator of intestinal inflammation. We have previously observed that pentoxifylline (PTX) attenuates burn-induced intestinal permeability and tight junction breakdown. We hypothesized that PTX would limit intestinal barrier breakdown and attenuate inflammatory signaling via the MAPK pathway.
methodsMale balb/c mice underwent 30% total body surface area full-thickness steam burn. Immediately after burn, animals received an intraperitoneal injection of PTX (12.5 mg/kg) in normal saline or normal saline alone. In vivo intestinal permeability to 4 kDa fluorescein isothiocyanate-dextran was measured. Intestinal extracts were obtained to measure interleukin-6 by enzyme-linked immunosorbent assay, and phosphorylated p38 MAPK, p38 MAPK, phosphorylated extracellular signal-related kinase (1/2) (ERK (1/2)), and ERK (1/2) by immunoblotting. Acute lung injury was assessed by histology at 24 hours after burn.
resultsAdministration of PTX immediately after injury attenuated burn-induced intestinal permeability. PTX also decreased the burn-induced phosphorylation of p38 MAPK and decreased phosphorylation of ERK (1/2) at 2 hours and 24 hours after injury. Animals given PTX had decreased intestinal interleukin-6 levels. A single dose of PTX also decreased histologic lung injury at 24 hours after burn.
conclusionPTX attenuates burn-induced intestinal permeability and subsequent intestinal inflammation. Use of PTX after burn was also associated with decreased acute lung injury. Because of its compelling anti-inflammatory effects, PTX may be an ideal candidate for use as an immunomodulatory adjunct to resuscitation fluid.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.