ArticleCell adhesion & migration
Microbial alkaloid staurosporine induces formation of nanometer-wide membrane tubular extensions (cytonemes, membrane tethers) in human neutrophils.
Article in Cell adhesion & migration. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The expanding family of neutrophil-derived extracellular vesicles.Immunological reviews · 2022Review
- Emerging targets signaling for inflammation in Parkinson's disease drug discovery.Metabolic brain disease · 2022Review
- Article
- Neutrophils-From Bone Marrow to First-Line Defense of the Innate Immune System.Frontiers in immunology · 2021Review
- Tunneling Nanotubes and Tumor Microtubes in Cancer.Cancers · 2020Review
- Cytonemes Versus Neutrophil Extracellular Traps in the Fight of Neutrophils with Microbes.International journal of molecular sciences · 2020Review
- Lost in translation: applying 2D intercellular communication via tunneling nanotubes in cell culture to physiologically relevant 3D microenvironments.The FEBS journal · 2017Review
- Mold Alkaloid Cytochalasin D Modifies the Morphology and Secretion of fMLP-, LPS-, or PMA-Stimulated Neutrophils upon Adhesion to Fibronectin.Mediators of inflammation · 2017Article
- Exosomes and nanotubes: Control of immune cell communication.The international journal of biochemistry & cell biology · 2016Review
- LRRK2 inhibitors and their potential in the treatment of Parkinson's disease: current perspectives.Clinical pharmacology : advances and applications · 2016Review
- Tumor exosomes induce tunneling nanotubes in lipid raft-enriched regions of human mesothelioma cells.Experimental cell research · 2014Article
- Intercellular communication in malignant pleural mesothelioma: properties of tunneling nanotubes.Frontiers in physiology · 2014Article
- Tunneling nanotubes provide a unique conduit for intercellular transfer of cellular contents in human malignant pleural mesothelioma.PloS one · 2012Article
- Membrane tubulovesicular extensions (cytonemes): secretory and adhesive cellular organelles.Cell adhesion & migrationReview
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present work, we demonstrate that microbial alkaloid staurosporine (STS) and Ro 31-8220, structurally related to STS protein kinase C inhibitor, caused development of membrane tubular extensions in human neutrophils upon adhesion to fibronectin-coated substrata. STS-induced tubular extensions interconnected neutrophils in a network and bound serum-opsonized bacteria Salmonella enterica serovar Typhimurium. The diameter of STS-induced extensions varied in the range 160-200 nm. The extensions were filled with cytoplasm and covered with membrane, as they included fluorescent cytoplasmic and lipid dyes. Neither protein kinase C inhibitors H-7 and bisindolylmaleimide VII, nor tyrosine protein kinase inhibitors tyrphostin AG 82 and genistein caused such extensions formation. Supposedly, STS induces membrane tubular extension formation promoting actin cytoskeleton depolymerization or affecting NO synthesis.
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