ArticlePhysiological genomics2010
Mislocalization of mitochondria and compromised renal function and oxidative stress resistance in Drosophila SesB mutants.
Article in Physiological genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
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- Effects of cadmium on oxidative stress and cell apoptosis in Drosophila melanogaster larvae.Scientific reports · 2022Article
- Metabolically active and polyploid renal tissues rely on graded cytoprotection to drive developmental and homeostatic stress resilience.Development (Cambridge, England) · 2021Article
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- Analysis of Gal4 Expression Patterns in AdultG3 (Bethesda, Md.) · 2020Article
- The septate junction protein Mesh is required for epithelial morphogenesis, ion transport, and paracellular permeability in theAmerican journal of physiology. Cell physiology · 2020Article
- Contrasting patterns of evolutionary constraint and novelty revealed by comparative sperm proteomic analysis in Lepidoptera.BMC genomics · 2017Article
- Characterization of two adenine nucleotide translocase paralogues in the stink bug,Journal of pesticide science · 2016Article
- The cell adhesion molecule Fasciclin2 regulates brush border length and organization in Drosophila renal tubules.Nature communications · 2016Article
- Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth.PloS one · 2016Article
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- Two adenine nucleotide translocase paralogues involved in cell proliferation and spermatogenesis in the silkworm Bombyx mori.PloS one · 2015Article
- Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease.Disease models & mechanisms · 2014Article
- The Drosophila effector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesB.The Journal of cell biology · 2014Article
- A biogenic amine and a neuropeptide act identically: tyramine signals through calcium in Drosophila tubule stellate cells.Proceedings. Biological sciences · 2013Article
- Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Mitochondria accumulate at sites of intense metabolic activity within cells, but the adaptive value of this placement is not clear. In Drosophila, sesB encodes the ubiquitous isoform of adenine nucleotide translocase (ANT, the mitochondrial inner membrane ATP/ADP exchanger); null alleles are lethal, whereas hypomorphic alleles display sensitivity to a range of stressors. In the adult renal tubule, which is densely packed with mitochondria and hence enriched for sesB, both hypomorphic alleles and RNA interference knockdowns cause the mitochondria to lose their highly polarized distribution in the tissue and to become rounded. Basal cytoplasmic and mitochondrial calcium levels are both increased, and neuropeptide calcium response compromised, with concomitant defects in fluid secretion. The remaining mitochondria in sesB mutants are overactive and maintain depleted cellular ATP levels while generating higher levels of hydrogen peroxide than normal. When sesB expression is knocked down in just tubule principal cells, the survival of the whole organism upon oxidative stress is reduced, implying a limiting role for the tubule in homeostatic response to stressors. The physiological impacts of defective ANT expression are thus widespread and diverse.
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Registered trials
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