ArticlePhysiological genomics2010
Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertension.
Article in Physiological genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- Dissociation of Hypertension and Renal Damage After Cessation of High-Salt Diet in Dahl Rats.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Transfer RNA Fragments in the Kidney in Hypertension.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Genetic susceptibility of hypertension-induced kidney disease.Physiological reports · 2021Review
- Endogenous miR-204 Protects the Kidney against Chronic Injury in Hypertension and Diabetes.Journal of the American Society of Nephrology : JASN · 2020Article
- NOX2-derived reactive oxygen species in immune cells exacerbates salt-sensitive hypertension.Free radical biology & medicine · 2020Article
- MiR-192-5p in the Kidney Protects Against the Development of Hypertension.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Role of DNA De Novo (De)Methylation in the Kidney in Salt-Induced Hypertension.Hypertension (Dallas, Tex. : 1979) · 2018Article
- MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension.Journal of the American Society of Nephrology : JASN · 2018Article
- Renal Tumor Necrosis Factor α Contributes to Hypertension in Dahl Salt-Sensitive Rats.Scientific reports · 2016Article
- Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Pappa2 is linked to salt-sensitive hypertension in Dahl S rats.Physiological genomics · 2016Article
- Null mutation of the nicotinamide adenine dinucleotide phosphate-oxidase subunit p67phox protects the Dahl-S rat from salt-induced reductions in medullary blood flow and glomerular filtration rate.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Characteristics of long non-coding RNAs in the Brown Norway rat and alterations in the Dahl salt-sensitive rat.Scientific reports · 2014Article
- Characterization of biological pathways associated with a 1.37 Mbp genomic region protective of hypertension in Dahl S rats.Physiological genomics · 2014Article
- Ultrastructure of mitochondria and the endoplasmic reticulum in renal tubules of Dahl salt-sensitive rats.American journal of physiology. Renal physiology · 2014Article
- Base-resolution maps of 5-methylcytosine and 5-hydroxymethylcytosine in Dahl S rats: effect of salt and genomic sequence.Hypertension (Dallas, Tex. : 1979) · 2014Article
- Epigenomics of hypertension.Seminars in nephrology · 2013Review
- Congenic mapping and sequence analysis of the Renin locus.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Increased proliferative cells in the medullary thick ascending limb of the loop of Henle in the Dahl salt-sensitive rat.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Mitochondrial proteomic analysis reveals deficiencies in oxygen utilization in medullary thick ascending limb of Henle in the Dahl salt-sensitive rat.Physiological genomics · 2012Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
Abstract
Chromosome 13 consomic and congenic rat strains were analyzed to investigate the pattern of genomic pathway utilization involved in protection against salt-sensitive hypertension and renal injury. Introgression of the entire Brown-Norway chromosome 13 (consomic SS-13(BN)) or nonoverlapping segments of this chromosome (congenic strains, 16 Mbp in D13Rat151-D13Rat197 or 14 Mbp in D13Rat111-D13Got22) into the genome of the Dahl salt-sensitive rat attenuated salt-induced hypertension and proteinuria. mRNA abundance profiles in the renal cortex and the renal medulla from rats receiving 0.4% or 8% NaCl diets revealed two important features of pathway recruitment in these rat strains. First, the two congenic strains shared alterations in several pathways compared with Dahl salt-sensitive rats, despite the fact that the genomic segments introgressed in the two congenic strains did not overlap. Second, even though the genomic segment introgressed in each congenic strain was a part of the chromosome introgressed in the consomic strain, pathways altered in each congenic strain were not simply a subset of those altered in the consomic. Supporting the relevance of the mRNA data, differential expression of oxidative stress-related genes among the four strains of rats was associated with differences in urinary excretion of lipid peroxidation products. The findings suggest that different genetic alterations might converge to influence shared pathways in protection from hypertension, and that, depending on the genomic context, the same genetic alteration might diverge to affect different pathways.
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