ReviewGenes & development2009
Overcoming inhibition in the spindle checkpoint.
Review in Genes & development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Kinetochore-catalyzed MCC formation: A structural perspective.IUBMB life · 2023Article
- Review
- Review
- A role for the spindle assembly checkpoint in the DNA damage response.Current genetics · 2017Article
- "Wait anaphase" signals are not confined to the mitotic spindle.Molecular biology of the cell · 2017Article
- Generation of a Spindle Checkpoint Arrest from Synthetic Signaling Assemblies.Current biology : CB · 2017Article
- Article
- The mitotic checkpoint complex (MCC): looking back and forth after 15 years.AIMS molecular science · 2016Article
- Thyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing protein.The Journal of biological chemistry · 2014Article
- Cyclin B3 and dynein heavy chain cooperate to increase fitness in the absence of mdf-1/MAD1 in Caenorhabditis elegans.Cell cycle (Georgetown, Tex.) · 2014Article
- A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B.The Journal of cell biology · 2012Article
- Proper cyclin B3 dosage is important for precision of metaphase-to-anaphase onset timing in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2012Article
- Mathematical modeling of fission yeast Schizosaccharomyces pombe cell cycle: exploring the role of multiple phosphatases.Systems and synthetic biology · 2011Article
- Monitoring the fidelity of mitotic chromosome segregation by the spindle assembly checkpoint.Cell proliferation · 2011Review
- KNL1/Spc105 recruits PP1 to silence the spindle assembly checkpoint.Current biology : CB · 2011Article
- Caenorhabditis elegans cyclin B3 is required for multiple mitotic processes including alleviation of a spindle checkpoint-dependent block in anaphase chromosome segregation.PLoS genetics · 2010Article
- Defining the molecular basis of BubR1 kinetochore interactions and APC/C-CDC20 inhibition.The Journal of biological chemistry · 2010Article
- Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells.Genes & development · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Spindle checkpoint silencing is a critical step during mitosis that initiates chromosome segregation, yet surprisingly little is known about its mechanism. Protein phosphatase I (PP1) was shown recently to be a key player in this process, and in this issue of Genes & Deverlopment, Akiyoshi and colleagues (pp. 2887-2899) identify budding yeast Fin1p as a kinetochore-localized regulator of PP1 activity toward checkpoint targets. Here we review recent mechanistic insights and propose a working model for spindle checkpoint silencing.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.