ArticleGenes & development2009
Transcriptional competence in pluripotency.
Article in Genes & development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Different SP1 binding dynamics at individual genomic loci in human cells.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease.Genes & development · 2021Review
- A Similar Speciation Process Relying on Cellular Stochasticity in Microbial and Cancer Cell Populations.iScience · 2020Review
- A Darwinian and Physical Look at Stem Cell Biology Helps Understanding the Role of Stochasticity in Development.Frontiers in cell and developmental biology · 2020Article
- Developmental regulation of DNA cytosine methylation at the immunoglobulin heavy chain constant locus.PLoS genetics · 2019Article
- Cancer Stem Cells: From Historical Roots to a New Perspective.Journal of oncology · 2019Review
- Foxi3 is necessary for the induction of the chick otic placode in response to FGF signaling.Developmental biology · 2014Article
- Setting appropriate boundaries: fate, patterning and competence at the neural plate border.Developmental biology · 2014Review
- The trithorax group protein Ash2l is essential for pluripotency and maintaining open chromatin in embryonic stem cells.The Journal of biological chemistry · 2013Article
- Mutant p53 is a transcriptional co-factor that binds to G-rich regulatory regions of active genes and generates transcriptional plasticity.Cell cycle (Georgetown, Tex.) · 2012Article
- SOX after SOX: SOXession regulates neurogenesis.Genes & development · 2011Article
- Pioneer transcription factors: establishing competence for gene expression.Genes & development · 2011Review
- Epigenetic mechanisms involved in developmental nutritional programming.World journal of diabetes · 2011Article
- Identification of a novel epigenetic regulatory region within the pluripotency associated microRNA cluster, EEmiRC.Nucleic acids research · 2011Article
- Pioneer factors in embryonic stem cells and differentiation.Current opinion in genetics & development · 2010Review
- Human pluripotent stem cells: from biology to cell therapy.World journal of stem cells · 2010Article
- The molecular basis of craniofacial placode development.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Embryonic stem (ES) cells possess a globally open, decondensed chromatin structure that, together with trans-acting factors, supports transcriptional competence of developmentally regulated genes. However, our understanding of the mechanisms that establish transcriptional competence of specific genes is limited. In this issue of Genes & Development, Xu and colleagues (pp. 2824-2838) show that tissue-specific enhancers are actively marked by an unmethylated window in ES cells and induced pluripotent stem (iPS) cells. They propose a model and present supporting evidence to demonstrate the active involvement of pioneer transcription factors in this process. This work marks an important step toward the understanding of the mechanisms that define and maintain pluripotency, and calls for the identification of the factors that participate in the establishment of transcriptional competence in pluripotent cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.