ArticleAntimicrobial agents and chemotherapy2010
Murine model of a disseminated infection by the novel fungus Fonsecaea monophora and successful treatment with posaconazole.
Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Establishment of epidemiological cutoff values againstJournal of clinical microbiology · 2026Article
- Cerebral Aspergillosis: Diagnostic Challenges, Therapeutic Strategies, and Future Research.CNS drugs · 2026Review
- Review
- Low Central Nervous System Posaconazole Concentrations during Cerebral Phaeohyphomycosis.Antimicrobial agents and chemotherapy · 2019Article
- Therapeutic Challenges of Non-Antimicrobial agents and chemotherapy · 2019Review
- Antifungal Drugs: Special Problems Treating Central Nervous System Infections.Journal of fungi (Basel, Switzerland) · 2019Article
- CYP51 as drug targets for fungi and protozoan parasites: past, present and future.Parasitology · 2018Review
- Cladophialophora bantiana osteomyelitis in a renal transplant patient.Medical mycology case reports · 2016Article
- Cerebral phaeohyphomycosis by Fonsecaea monophora: Report in a patient with AIDS and a ring enhancing lesion.Medical mycology case reports · 2016Article
- Black yeasts and their filamentous relatives: principles of pathogenesis and host defense.Clinical microbiology reviews · 2014Review
- Antifungal susceptibility patterns of opportunistic fungi in the genera Verruconis and Ochroconis.Antimicrobial agents and chemotherapy · 2014Article
- Tissue penetration of antifungal agents.Clinical microbiology reviews · 2014Review
- VNI cures acute and chronic experimental Chagas disease.The Journal of infectious diseases · 2013Article
- Antifungal therapy in an athymic murine model of chromoblastomycosis by Fonsecaea pedrosoi.Antimicrobial agents and chemotherapy · 2011Article
- Melanized fungi in human disease.Clinical microbiology reviews · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have evaluated the efficacy of posaconazole, amphotericin B, and itraconazole in a murine model of disseminated infection by Fonsecaea monophora. Of these three antifungal drugs tested, posaconazole prolonged survival significantly and reduced the fungal load in most of the organs tested. Bioassay studies demonstrated the relationship between posaconazole levels and dose escalation in serum and brain tissue. Posaconazole may have a clinical role in the treatment of disseminated infections by F. monophora.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.