ArticleArchives of ophthalmology (Chicago, Ill. : 1960)2009
Melanoma-associated retinopathy: a paraneoplastic autoimmune complication.
Article in Archives of ophthalmology (Chicago, Ill. : 1960), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Paraneoplastic ocular syndrome: a pandora's box of underlying malignancies.Eye (London, England) · 2022Pooled it
- Electronegative ERG revealing melanoma-associated retinopathy in a patient with trametinib-associated retinopathy.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Paraneoplastic syndromes and the retina.Current opinion in ophthalmology · 2026Review
- Article
- Case Report: Longitudinal Evaluation and Treatment of a Melanoma-Associated Retinopathy Patient.Research square · 2024Article
- Case report: Longitudinal evaluation and treatment of a melanoma-associated retinopathy patient.Frontiers in medicine · 2024Article
- Relation between ocular paraneoplastic syndromes and Immune Checkpoint Inhibitors (ICI): review of literature.Journal of ophthalmic inflammation and infection · 2023Review
- Assessment of Retinal Pigment Epithelium Alterations and Chorioretinal Vascular Network Analyses in Patients under Treatment with BRAF/MEK Inhibitor for Different Malignancies: A Pilot Study.Journal of clinical medicine · 2023Article
- Paraneoplastic syndrome in neuroophthalmology.Journal of neurology · 2022Review
- Expression of Autoimmunity-Related Genes in Melanoma.Cancers · 2022Article
- Ocular adverse events associated with immune checkpoint inhibitors: a novel multidisciplinary management algorithm.Therapeutic advances in medical oncology · 2021Article
- Importance of Autoimmune Responses in Progression of Retinal Degeneration Initiated by Gene Mutations.Frontiers in medicine · 2021Review
- A case of melanoma-associated retinopathy with autoantibodies against TRPM1.Documenta ophthalmologica. Advances in ophthalmology · 2020Article
- Retinal Diseases that Can Masquerade as Neurological Causes of Vision Loss.Current neurology and neuroscience reports · 2020Review
- A Case of Melanoma-Associated Retinopathy, Uveitis, and Optic Neuritis Associated With Pembrolizumab, Managed With Topical, Intravitreal, and Intravenous Steroids.Journal of vitreoretinal diseases · 2020Article
- Occurrence of major anti-retinal autoantibodies associated with paraneoplastic autoimmune retinopathy.Clinical immunology (Orlando, Fla.) · 2020Article
- Identification and characterization of novel TRPM1 autoantibodies from serum of patients with melanoma-associated retinopathy.PloS one · 2020Article
- TRPM1 Autoantibodies in Melanoma Patients Without Self-Reported Visual Symptoms.Investigative ophthalmology & visual science · 2019Article
- Neuronal Antibodies and Associated Syndromes.Autoimmune diseases · 2019Review
- Typical electronegative electroretinography and nyctalopia as a presenting feature of systemic malignant melanoma.International medical case reports journal · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesTo study 11 patients with melanoma-associated retinopathy (MAR) to clarify the reliability of various methods of diagnostic testing, to determine the underlying antigenic retinal proteins, and to study the clinical histories and types of associated melanomas.
methodsClinical data were obtained from patients with melanoma who developed marked visual problems. Testing included electroretinography, kinetic visual fields, comparative studies of Western blots, and indirect immunohistologic examination to detect antiretinal antibodies, as well as proteomic studies to identify underlying antigenic retinal proteins.
resultsPatients with MAR typically have rapid onset of photopsias, scotomata, and loss of central or paracentral vision. Ophthalmoscopy seldom shows significant changes early, but electroretinograms are abnormal. Results of Western blots and immunohistologic examination can show antiretinal antibodies but not always. Most patients (9 of 11) had a strong family history of autoimmune disorders. Any type of melanoma (cutaneous, choroidal, ciliary body, or choroidal nevi) may be associated with this paraneoplastic autoimmune reactivity. MAR may precede or follow the diagnosis of melanoma. Patients with MAR have the same antigenic retinal proteins that have been associated with cancer-associated retinopathy. In addition, 2 new antigenic retinal proteins, aldolase A and aldolase C, were found.
conclusionsThere was a high prevalence of positive family histories of autoimmune disease in patients with MAR. To confirm the disorder, multiple clinical and serum diagnostic techniques (Western blot or indirect immunohistologic examination) are needed. Two newly observed antigenic retinal proteins, aldolase A and aldolase C, are associated with MAR.
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