ArticleInfection and immunity2010
Activation of platelets by Aspergillus fumigatus and potential role of platelets in the immunopathogenesis of Aspergillosis.
Article in Infection and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- Beyond hemostasis, the immunomodulatory nature of platelets.Research and practice in thrombosis and haemostasis · 2025Review
- Seroprevalence and prognostic value of Aspergillus-specific IgG among non-neutropenic invasive pulmonary aspergillosis patients: a prospective multicenter study.Pneumonia (Nathan Qld.) · 2024Article
- Preliminary Study on the Host Response to Bivalent and Monovalent Autogenous Vaccines againstVeterinary sciences · 2022Article
- Serum Cytokines Usefulness for Understanding the Pathology in Allergic Bronchopulmonary Aspergillosis and Chronic Pulmonary Aspergillosis.Journal of fungi (Basel, Switzerland) · 2022Article
- Article
- Platelets in pediatric and neonatal sepsis: novel mediators of the inflammatory cascade.Pediatric research · 2022Review
- Neutrophil-Specific Knockdown of β2 Integrins Impairs Antifungal Effector Functions and Aggravates the Course of Invasive Pulmonal Aspergillosis.Frontiers in immunology · 2022Article
- Platelets: a potential role in chronic respiratory diseases?European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Dysregulation of Key Proteinases inReports of biochemistry & molecular biology · 2021Article
- GP IIb/IIIa-Mediated Platelet Activation and Its Modulation of the Immune Response of Monocytes AgainstFrontiers in cellular and infection microbiology · 2021Article
- Capillary Electrophoresis Assessment of Plasma Protein Changes in an African Penguin (ACS omega · 2020Article
- Differential genes expression analysis of invasive aspergillosis: a bioinformatics study based on mRNA/microRNA.Molecular biology research communications · 2020Article
- Platelets are critical for survival and tissue integrity during murine pulmonary Aspergillus fumigatus infection.PLoS pathogens · 2020Article
- CD11b Regulates Fungal Outgrowth but Not Neutrophil Recruitment in a Mouse Model of Invasive Pulmonary Aspergillosis.Frontiers in immunology · 2019Article
- Human NK cells adapt their immune response towards increasing multiplicities of infection of Aspergillus fumigatus.BMC immunology · 2018Article
- First Line of Defense: Innate Cell-Mediated Control of Pulmonary Aspergillosis.Frontiers in microbiology · 2016Review
- Antifungal innate immunity: recognition and inflammatory networks.Seminars in immunopathology · 2015Review
- Platelet parameters and (1, 3)-β-D-glucan as a diagnostic and prognostic marker of invasive fungal disease in preterm infants.PloS one · 2015Article
- Integrated inference and evaluation of host-fungi interaction networks.Frontiers in microbiology · 2015Article
- Cytokine network in scrub typhus: high levels of interleukin-8 are associated with disease severity and mortality.PLoS neglected tropical diseases · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aspergillus fumigatus is the most frequent cause of invasive mold infections worldwide. Platelets contribute to inflammation and promote thrombosis, characteristically seen in aspergillosis, and might be involved both in antifungal defense and in the histopathological process. In the experiments reported here, in vitro activation of platelets by conidia, swollen conidia, and hyphae from A. fumigatus was assessed by flow cytometry and enzyme immunoassays. THP-1 monocytes and human monocytes with and without platelets were cultured with hyphae from A. fumigatus, and the release of interleukin-8 (IL-8) was measured by enzyme immunoassays. A. fumigatus potently induced the expression of CD62-p and CD63 and the release of CD40 ligand, RANTES, and Dickkopf homolog 1 in platelets, with particularly enhancing effects of hyphae compared with conidia. The hypha-mediated activation of platelets further enhanced the release of IL-8 both in THP-1 monocytes and in human adherent monocytes. In conclusion, we have found that A. fumigatus is a potent inducer of platelet-mediated inflammation, potentially promoting protective as well as harmful responses during aspergillosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.