ArticleInfection and immunity2010
Salicylic acid diminishes Staphylococcus aureus capsular polysaccharide type 5 expression.
Article in Infection and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Diflunisal and Analogue Pharmacophores Mediating Suppression of Virulence Phenotypes inAntibiotics (Basel, Switzerland) · 2023Article
- Effect of Savirin or Ticagrelor Treatment on the Expression of Commonly Used Reference Genes inMicroorganisms · 2023Article
- Regulation of Staphylococcal Capsule by SarZ is SigA-Dependent.Journal of bacteriology · 2022Article
- Role of sodium salicylate inFrontiers in microbiology · 2022Article
- Within-Host Adaptation ofInternational journal of molecular sciences · 2021Article
- Salicylic acid stabilizes Staphylococcus aureus biofilm by impairing the agr quorum-sensing system.Scientific reports · 2021Article
- MgrA Activates Staphylococcal Capsule via SigA-Dependent Promoter.Journal of bacteriology · 2020Article
- Sodium salicylate interferes with quorum-sensing-regulated virulence in chronic wound isolates ofJournal of medical microbiology · 2020Article
- MgrA Negatively Impacts Staphylococcus aureus Invasion by Regulating Capsule and FnbA.Infection and immunity · 2019Article
- Aspirin Effect onFrontiers in medicine · 2019Review
- Neutrophil Functional Heterogeneity: Identification of Competitive Phagocytosis.Frontiers in immunology · 2017Article
- The Active Component of Aspirin, Salicylic Acid, PromotesFrontiers in microbiology · 2017Article
- Editorial on low-dose acetylsalicylic acid treatment and impact on short-term mortality in Staphylococcus aureus bloodstream infection: a propensity score-matched cohort study.Annals of translational medicine · 2016Article
- Combating pathogenic microorganisms using plant-derived antimicrobials: a minireview of the mechanistic basis.BioMed research international · 2014Review
- Rapid and reliable identification of Staphylococcus aureus capsular serotypes by means of artificial neural network-assisted Fourier transform infrared spectroscopy.Journal of clinical microbiology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Capsular polysaccharides (CP) of serotypes 5 (CP5) and 8 (CP8) are major Staphylococcus aureus virulence factors. Previous studies have shown that salicylic acid (SAL), the main aspirin metabolite, affects the expression of certain bacterial virulence factors. In the present study, we found that S. aureus strain Reynolds (CP5) cultured with SAL was internalized by MAC-T cells in larger numbers than strain Reynolds organisms not exposed to SAL. Furthermore, the internalization of the isogenic nonencapsulated Reynolds strain into MAC-T cells was not significantly affected by preexposure to SAL. Pretreatment of S. aureus strain Newman with SAL also enhanced internalization into MAC-T cells compared with that of untreated control strains. Using strain Newman organisms, we evaluated the activity of the major cap5 promoter, which was significantly decreased upon preexposure to SAL. Diminished transcription of mgrA and upregulation of the saeRS transcript, both global regulators of CP expression, were found in S. aureus cultured in the presence of SAL, as ascertained by real-time PCR analysis. In addition, CP5 production by S. aureus Newman was also decreased by treatment with SAL. Collectively, our data demonstrate that exposure of encapsulated S. aureus strains to low concentrations of SAL reduced CP production, thus unmasking surface adhesins and leading to an increased capacity of staphylococci to invade epithelial cells. The high capacity of internalization of the encapsulated S. aureus strains induced by SAL pretreatment may contribute to the persistence of bacteria in certain hosts.
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