ArticleNucleic acids research2010
Large-scale discovery of insertion hotspots and preferential integration sites of human transposed elements.
Article in Nucleic acids research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- The pQBR mercury resistance plasmids: a model set of sympatric environmental mobile genetic elements.Microbial genomics · 2026Article
- A recent and rapid genome expansion driven by the amplification of transposable elements in the Neotropical annual killifish Garcialebias charrua.Biological research · 2025Article
- Chromatin unfolding via loops can drive clustered transposon insertion.Biophysical journal · 2025Article
- Direct identification ofbioRxiv : the preprint server for biology · 2025Article
- How our brains are built: emerging approaches to understand human-specific features.Current opinion in genetics & development · 2024Review
- The Evolution of Widespread Recombination Suppression on the Dwarf Hamster (Phodopus) X Chromosome.Genome biology and evolution · 2022Article
- A Field Guide to Eukaryotic Transposable Elements.Annual review of genetics · 2020Review
- Unraveling epigenomic abnormality in azoospermic human males by WGBS, RNA-Seq, and transcriptome profiling analyses.Journal of assisted reproduction and genetics · 2020Article
- Article
- Whole-genome sequencing reveals principles of brain retrotransposition in neurodevelopmental disorders.Cell research · 2018Article
- Evolutionary Rewiring of Human Regulatory Networks by Waves of Genome Expansion.American journal of human genetics · 2018Article
- LTR_retriever: A Highly Accurate and Sensitive Program for Identification of Long Terminal Repeat Retrotransposons.Plant physiology · 2018Article
- L1 retrotransposition in the soma: a field jumping ahead.Mobile DNA · 2018Review
- Article
- Phylogenomic analysis reveals splicing as a mechanism of parallel evolution of non-canonical SVAs in hominine primates.Mobile DNA · 2018Article
- Genomic landscape of human, bat, and ex vivo DNA transposon integrations.Molecular biology and evolution · 2014Article
- Detecting Alu insertions from high-throughput sequencing data.Nucleic acids research · 2013Article
- Characterization of transcriptional activation and inserted-into-gene preference of various transposable elements in the Brassica species.Molecular biology reports · 2012Article
- Whole genome resequencing reveals natural target site preferences of transposable elements in Drosophila melanogaster.PloS one · 2012Article
- Alu pair exclusions in the human genome.Mobile DNA · 2011Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Throughout evolution, eukaryotic genomes have been invaded by transposable elements (TEs). Little is known about the factors leading to genomic proliferation of TEs, their preferred integration sites and the molecular mechanisms underlying their insertion. We analyzed hundreds of thousands nested TEs in the human genome, i.e. insertions of TEs into existing ones. We first discovered that most TEs insert within specific 'hotspots' along the targeted TE. In particular, retrotransposed Alu elements contain a non-canonical single nucleotide hotspot for insertion of other Alu sequences. We next devised a method for identification of integration sequence motifs of inserted TEs that are conserved within the targeted TEs. This method revealed novel sequences motifs characterizing insertions of various important TE families: Alu, hAT, ERV1 and MaLR. Finally, we performed a global assessment to determine the extent to which young TEs tend to nest within older transposed elements and identified a 4-fold higher tendency of TEs to insert into existing TEs than to insert within non-TE intergenic regions. Our analysis demonstrates that TEs are highly biased to insert within certain TEs, in specific orientations and within specific targeted TE positions. TE nesting events also reveal new characteristics of the molecular mechanisms underlying transposition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.