ArticleThe Journal of physiology2010
Cones perform a non-linear transformation on natural stimuli.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Origin and functional impact of early nonlinearities in primate retina.bioRxiv : the preprint server for biology · 2026Article
- Predictably manipulating photoreceptor light responses to reveal their role in downstream visual responses.eLife · 2024Article
- Applying Super-Resolution and Tomography Concepts to Identify Receptive Field Subunits in the Retina.PLoS computational biology · 2024Article
- Predictably manipulating photoreceptor light responses to reveal their role in downstream visual responses.bioRxiv : the preprint server for biology · 2024Article
- Systematic reduction of the dimensionality of natural scenes allows accurate predictions of retinal ganglion cell spike outputs.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Colour discrimination thresholds vary throughout colour space in a reef fish (Rhinecanthus aculeatus).The Journal of experimental biology · 2022Article
- Simple model for encoding natural images by retinal ganglion cells with nonlinear spatial integration.PLoS computational biology · 2022Article
- Predicting and Manipulating Cone Responses to Naturalistic Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Enhancing the dark side: asymmetric gain of cone photoreceptors underpins their discrimination of visual scenes based on skewness.The Journal of physiology · 2022Article
- Nonlinear spatial integration in retinal bipolar cells shapes the encoding of artificial and natural stimuli.Neuron · 2021Article
- A computational observer model of spatial contrast sensitivity: Effects of photocurrent encoding, fixational eye movements, and inference engine.Journal of vision · 2020Article
- Probing Computation in the Primate Visual System at Single-Cone Resolution.Annual review of neuroscience · 2019Review
- S-cone photoreceptors in the primate retina are functionally distinct from L and M cones.eLife · 2019Article
- A novel mechanism of cone photoreceptor adaptation.PLoS biology · 2017Article
- Extracellular ATP hydrolysis inhibits synaptic transmission by increasing ph buffering in the synaptic cleft.PLoS biology · 2014Article
- Visual pattern discrimination by population retinal ganglion cells' activities during natural movie stimulation.Cognitive neurodynamics · 2014Article
- Dynamical adaptation in photoreceptors.PLoS computational biology · 2013Article
- Developmental and functional expression of miRNA-stability related genes in the nervous system.PloS one · 2013Article
- Biologic scaffolds composed of central nervous system extracellular matrix.Biomaterials · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visual information in natural scenes is distributed over a broad range of intensities and contrasts. This distribution has to be compressed in the retina to match the dynamic range of retinal neurons. In this study we examined how cones perform this compression and investigated which physiological processes contribute to this operation. M- and L-cones of the goldfish were stimulated with a natural time series of intensities (NTSI) and their responses were recorded. The NTSI displays an intensity distribution which is skewed towards the lower intensities and has a long tail into the high intensity region. Cones transform this skewed distribution into a more symmetrical one. The voltage responses of the goldfish cones were compared to those of a linear filter and a non-linear biophysical model of the photoreceptor. The results show that the linear filter under-represents contrasts at low intensities compared to the actual cone whereas the non-linear biophysical model performs well over the whole intensity range used. Quantitative analysis of the two approaches indicates that the non-linear biophysical model can capture 91 +/- 5% of the coherence rate (a biased measure of information rate) of the actual cone, where the linear filter only reaches 48 +/- 8%. These results demonstrate that cone photoreceptors transform an NTSI in a non-linear fashion. The comparison between current clamp and voltage clamp recordings and analysis of the behaviour of the biophysical model indicates that both the calcium feedback loop in the outer segment and the hydrolysis of cGMP are the major components that introduce the specific non-linear response properties found in the goldfish cones.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.