ArticleMolecular biology and evolution2010
Recombination yet inefficient selection along the Drosophila melanogaster subgroup's fourth chromosome.
Article in Molecular biology and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- A population genomic resource for Drosophila pseudoobscura.G3 (Bethesda, Md.) · 2026Article
- Population genomics ofbioRxiv : the preprint server for biology · 2026Article
- Recombination Suppression Drives Expansion of the Drosophila Dot Chromosome.Molecular biology and evolution · 2025Article
- The Scorpionfly (Panorpa cognata) Genome Highlights Conserved and Derived Features of the Peculiar Dipteran X Chromosome.Molecular biology and evolution · 2023Article
- Selection and geography shape male reproductive tract transcriptomes in Drosophila melanogaster.Genetics · 2023Article
- Changing Population Size in McDonald-Kreitman Style Analyses: Artifactual Correlations and Adaptive Evolution between Humans and Chimpanzees.Genome biology and evolution · 2022Article
- Factors That Affect the Rates of Adaptive and Nonadaptive Evolution at the Gene Level in Humans and Chimpanzees.Genome biology and evolution · 2022Article
- Recombination Facilitates Adaptive Evolution in Rhizobial Soil Bacteria.Molecular biology and evolution · 2021Article
- Sex Chromosome Evolution in Muscid Flies.G3 (Bethesda, Md.) · 2020Article
- TheGenetics · 2018Article
- Support for the Dominance Theory inGenetics · 2018Article
- Retrotransposons Are the Major Contributors to the Expansion of theG3 (Bethesda, Md.) · 2017Article
- The house fly Y Chromosome is young and minimally differentiated from its ancient X Chromosome partner.Genome research · 2017Article
- Genomic changes following the reversal of a Y chromosome to an autosome in Drosophila pseudoobscura.Evolution; international journal of organic evolution · 2017Article
- Nucleotide diversity inflation as a genome-wide response to experimental lifespan extension in Drosophila melanogaster.BMC genomics · 2017Article
- Article
- Adaptive Evolution Is Substantially Impeded by Hill-Robertson Interference in Drosophila.Molecular biology and evolution · 2016Article
- Molecular Evolution of Drosophila Germline Stem Cell and Neural Stem Cell Regulating Genes.Genome biology and evolution · 2015Article
- The Evolutionary Tempo of Sex Chromosome Degradation in Carica papaya.Journal of molecular evolution · 2015Article
- Ancestral Chromatin Configuration Constrains Chromatin Evolution on Differentiating Sex Chromosomes in Drosophila.PLoS genetics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
A central goal of evolutionary genetics is an understanding of the forces responsible for the observed variation, both within and between species. Theoretical and empirical work have demonstrated that genetic recombination contributes to this variation by breaking down linkage between nucleotide sites, thus allowing them to behave independently and for selective forces to act efficiently on them. The Drosophila fourth chromosome, which is believed to experience no-or very low-rates of recombination has been an important model for investigating these effects. Despite previous efforts, central questions regarding the extent of recombination and the predominant modes of selection acting on it remain open. In order to more comprehensively test hypotheses regarding recombination and its potential influence on selection along the fourth chromosome, we have resequenced regions from most of its genes from Drosophila melanogaster, D. simulans, and D. yakuba. These data, along with available outgroup sequence, demonstrate that recombination is low but significantly greater than zero for the three species. Despite there being recombination, there is strong evidence that its frequency is low enough to have rendered selection relatively inefficient. The signatures of relaxed constraint can be detected at both the level of polymorphism and divergence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.