ArticleCarcinogenesis2010
Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats.
Article in Carcinogenesis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Maternal weight during pregnancy and risk of childhood acute lymphoblastic leukemia in offspring.Leukemia · 2025Article
- GCM2 Silencing in Parathyroid Adenoma Is Associated With Promoter Hypermethylation and Gain of Methylation on Histone 3.The Journal of clinical endocrinology and metabolism · 2021Article
- Methylation Dynamics ofCancers · 2019Review
- Gestational oral low-dose estradiol-17β induces altered DNA methylation of CDKN2D and PSAT1 in embryos and adult offspring.Scientific reports · 2018Article
- Oral Contraceptive Use May Modulate Global Genomic DNA Methylation and Promoter Methylation of APC1 and ESR1Asian Pacific journal of cancer prevention : APJCP · 2017Article
- Modification of the association between recreational physical activity and survival after breast cancer by promoter methylation in breast cancer-related genes.Breast cancer research : BCR · 2017Article
- DNA methylation modifies the association between obesity and survival after breast cancer diagnosis.Breast cancer research and treatment · 2016Article
- Article
- Exposure to estrogen and ionizing radiation causes epigenetic dysregulation, activation of mitogen-activated protein kinase pathways, and genome instability in the mammary gland of ACI rats.Cancer biology & therapy · 2013Article
- Gender-dependent miR-375 promoter methylation and the risk of type 2 diabetes.Experimental and therapeutic medicine · 2013Article
- Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention.Current cancer drug targets · 2013Review
- Epigenetic regulation of estrogen signaling in breast cancer.Epigenetics · 2013Review
- Article
- Intrauterine growth restriction affects hippocampal dual specificity phosphatase 5 gene expression and epigenetic characteristics.Physiological genomics · 2011Article
- Body mass and DNA promoter methylation in breast tumors in the Western New York Exposures and Breast Cancer Study.The American journal of clinical nutrition · 2011Article
- MicroRNA-mediated drug resistance in breast cancer.Clinical epigenetics · 2011Article
- Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intake.PLoS genetics · 2010Article
- Gene-Specific Promoter Methylation Status in Hormone-Receptor-Positive Breast Cancer Associates with Postmenopausal Body Size and Recreational Physical Activity.International journal of cancer and clinical researchArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Breast cancer, the most common malignancy in women, emerges through a multistep process, encompassing the progressive sequential evolution of morphologically distinct stages from a normal cell to hyperplasia (with and without atypia), carcinoma in situ, invasive carcinoma and metastasis. The success of treatment of breast cancer could be greatly improved by the detection at early stages of cancer. In the present study, we investigated the underlying molecular mechanisms involved in breast carcinogenesis in Augustus and Copenhagen-Irish female rats, a cross between the ACI strains, induced by continuous exposure to 17beta-estradiol. The results of our study demonstrate that early stages of estrogen-induced breast carcinogenesis are characterized by altered global DNA methylation, aberrant expression of proteins responsible for the proper maintenance of DNA methylation pattern and epigenetic silencing of the critical Rassf1a (Ras-association domain family 1, isoform A) tumor suppressor gene. Interestingly, transcriptional repression of the Rassf1a gene in mammary glands during early stages of breast carcinogenesis was associated with an increase in trimethylation of histones H3 lysine 9 and H3 lysine 27 and de novo CpG island methylation and at the Rassf1a promoter and first exon. In conclusion, we demonstrate that epigenetic alterations precede formation of preneoplastic lesions indicating the significance of epigenetic events in induction of oncogenic pathways in early stages of carcinogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.