ArticleHematology. American Society of Hematology. Education Program2009
Hereditary hemochromatosis: insights from the Hemochromatosis and Iron Overload Screening (HEIRS) Study.
Article in Hematology. American Society of Hematology. Education Program, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- EMQN best practice guidelines for the molecular genetic diagnosis of hereditary hemochromatosis (HH).European journal of human genetics : EJHG · 2016Guideline
- Increased Risk of Fracture Among Patients With Iron Overload: A Population-based Matched Cohort Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Article
- Hemochromatosis: Ferroptosis, ROS, Gut Microbiome, and Clinical Challenges with Alcohol as Confounding Variable.International journal of molecular sciences · 2024Review
- Paroxysmal atrial fibrillation and hemochromatosis: a narrative review.Annals of medicine and surgery (2012) · 2024Review
- Pathogenesis, Diagnosis, and Clinical Implications of Hereditary Hemochromatosis-The Cardiological Point of View.Diagnostics (Basel, Switzerland) · 2021Review
- Interplay Between Iron Overload and Osteoarthritis: Clinical Significance and Cellular Mechanisms.Frontiers in cell and developmental biology · 2021Review
- An efficient machine learning-based approach for screening individuals at risk of hereditary haemochromatosis.Scientific reports · 2020Article
- A chaotic viewpoint-based approach to solve haplotype assembly using hypergraph model.PloS one · 2020Article
- Serum ferritin levels at diagnosis predict prognosis in patients with low blast count myelodysplastic syndromes.International journal of hematology · 2019Article
- Polycythemia in Patients With Hereditary Hemochromatosis: Real or Myth?Journal of clinical medicine research · 2019Article
- "Let my liver rather heat with wine" - a review of hepatic fibrosis pathophysiology and emerging therapeutics.Hepatic medicine : evidence and research · 2019Article
- Influence of Iron on Bone Homeostasis.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Haemochromatosis.Nature reviews. Disease primers · 2018Review
- Ethnic and genetic factors of iron status in women of reproductive age.The American journal of clinical nutrition · 2017Observational
- Genome-wide association study of iron traits and relation to diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): potential genomic intersection of iron and glucose regulation?Human molecular genetics · 2017Article
- Effect of the Hemochromatosis Mutations on Iron Overload among the Indian β Thalassemia Carriers.Journal of clinical laboratory analysis · 2017Article
- Population Screening for Hereditary Haemochromatosis in Australia: Construction and Validation of a State-Transition Cost-Effectiveness Model.PharmacoEconomics - open · 2017Article
- Clinical Impact and Cellular Mechanisms of Iron Overload-Associated Bone Loss.Frontiers in pharmacology · 2017Review
- Iron and non-alcoholic fatty liver disease.World journal of gastroenterology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hemochromatosis comprises a group of inherited disorders resulting from mutations of genes involved in regulating iron metabolism. The multicenter, multi-ethnic Hemochromatosis and Iron Overload Screening (HEIRS) Study screened approximately 100,000 participants in the US and Canada, testing for HFE mutations, serum ferritin and transferrin saturation. As in other studies, HFE C282Y homozygosity was common in Caucasians but rare in other ethnic groups, and there was a marked heterogeneity of disease expression in C282Y homozygotes. Nevertheless, this genotype was often associated with elevations of serum ferritin and transferrin saturation and with iron stores of more than four grams in men but not in women. If liver biopsy was performed, in some cases because of evidence of hepatic dysfunction, fibrosis or cirrhosis was often found. Combined elevations of serum ferritin and transferrin saturation were observed in non-C282Y homozygotes of all ethnic groups, most prominently Asians, but not often with iron stores of more than four grams. Future studies to discover modifier genes that affect phenotypic expression in C282Y hemochromatosis should help identify patients who are at greatest risk of developing iron overload and who may benefit from continued monitoring of iron status to detect progressive iron loading.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.