ArticleThe American journal of pathology2010
Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction.
Article in The American journal of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03617965 (Mortality Due to Septic Shock Associated With Thrombocytopenia in the Intensive Care Unit), which is not on this map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mortality Due to Septic Shock Associated With Thrombocytopenia in the Intensive Care Unit
Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- Low platelet count as risk factor for infections in patients with primary immune thrombocytopenia: a retrospective evaluation.Annals of hematology · 2018Trial
- A multicellular vessel-on-a-chip model reveals context-dependent roles for platelets in inflammation and inflammatory hemostasis.Blood vessels, thrombosis & hemostasis · 2024Article
- Endothelial dysfunction as a factor leading to arterial hypertension.Pediatric nephrology (Berlin, Germany) · 2023Article
- Association of platelet count with all-cause mortality from acute respiratory distress syndrome: A cohort study.Journal of clinical laboratory analysis · 2022Article
- Review
- Review
- Platelets docking to VWF prevent leaks during leukocyte extravasation by stimulating Tie-2.Blood · 2020Article
- High mobility group box protein 1 neutralization therapy in ovine bacteremia: Lessons learned from an ovine septic shock model incorporating intensive care support.Experimental and therapeutic medicine · 2019Article
- Platelets Are at the Nexus of Vascular Diseases.Frontiers in cardiovascular medicine · 2019Review
- Glycoprotein VI in securing vascular integrity in inflamed vessels.Research and practice in thrombosis and haemostasis · 2018Article
- Apolipoprotein A-I Modulates Atherosclerosis Through Lymphatic Vessel-Dependent Mechanisms in Mice.Journal of the American Heart Association · 2017Article
- Platelets in Pulmonary Immune Responses and Inflammatory Lung Diseases.Physiological reviews · 2016Review
- P‑selectin increases angiotensin II‑induced cardiac inflammation and fibrosis via platelet activation.Molecular medicine reports · 2016Article
- Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia.The Journal of experimental medicine · 2015Article
- Platelets: essential components of the immune system.Current trends in immunology · 2015Article
- Neutrophil Phagocytosis of Platelets in the Early Phase of 2,4,6-trinitro-1-chlorobenzene (TNCB)-induced Dermatitis in Mice.Acta histochemica et cytochemica · 2014Article
- Platelets in inflammation: regulation of leukocyte activities and vascular repair.Frontiers in immunology · 2014Review
- Inhibition of platelet activation by clopidogrel prevents hypertension-induced cardiac inflammation and fibrosis.Cardiovascular drugs and therapy · 2013Article
- The vascular endothelium and human diseases.International journal of biological sciences · 2013Review
- Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum.Seminars in immunopathology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platelets have been shown to be important in inflammation, but their role in the cutaneous Arthus reaction remains unclear. To assess the role of platelets in this pathogenetic process, the cutaneous Arthus reaction was examined in wild-type mice and mice lacking E-selectin, P-selectin, or P-selectin glycoprotein ligand-1 (PSGL-1) with or without platelet depletion by busulfan, a bone marrow precursor cell-specific toxin. Edema and hemorrhage induced by immune complex challenge significantly decreased in busulfan-treated wild-type mice compared with untreated mice. Busulfan treatment did not affect edema and hemorrhage in P-selectin- or PSGL-1-deficient mice, suggesting that the effect by busulfan is dependent on P-selectin and PSGL-1 expression. The inhibited edema and hemorrhage paralleled reduced infiltration of neutrophils and mast cells and reduced levels of circulating platelets. Increased cutaneous production of interleukin-6, tumor necrosis factor-alpha, and platelet-derived chemokines during Arthus reaction was inhibited in busulfan-treated wild-type mice relative to untreated mice, which paralleled the reduction in cutaneous inflammation. Flow cytometric analysis showed that immune complex challenge generated blood platelet-leukocyte aggregates that decreased by busulfan treatment. In thrombocytopenic mice, the cutaneous inflammation after immune complex challenge was restored by platelet infusion. These results suggest that platelets induce leukocyte recruitment into skin by forming platelet-leukocyte aggregates and secreting chemokines at inflamed sites, mainly through the interaction of P-selectin on platelets with PSGL-1 on leukocytes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.