ArticleEukaryotic cell2010
Iron regulation through the back door: iron-dependent metabolite levels contribute to transcriptional adaptation to iron deprivation in Saccharomyces cerevisiae.
Article in Eukaryotic cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Iron Deficiency and Recovery in Yeast: A Quantitative Proteomics Approach.Journal of proteome research · 2021Article
- Yeast optimizes metal utilization based on metabolic network and enzyme kinetics.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Yeast Translation Elongation Factor eIF5A Expression Is Regulated by Nutrient Availability through Different Signalling Pathways.International journal of molecular sciences · 2020Article
- Proteomic profiling of the monothiol glutaredoxin Grx3 reveals its global role in the regulation of iron dependent processes.PLoS genetics · 2020Article
- Functional networks of co-expressed genes to explore iron homeostasis processes in the pathogenic yeastNAR genomics and bioinformatics · 2020Article
- Commonalities and Differences in the Transcriptional Response of the Model FungusFrontiers in microbiology · 2020Article
- Iron Regulatory Mechanisms inFrontiers in microbiology · 2020Review
- A comprehensive mechanistic model of iron metabolism in Saccharomyces cerevisiae.Metallomics : integrated biometal science · 2019Article
- Yeast expression of mammalian Onzin and fungal FCR1 suggests ancestral functions of PLAC8 proteins in mitochondrial metabolism and DNA repair.Scientific reports · 2019Article
- mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The CCAAT-Binding Complex Controls Respiratory Gene Expression and Iron Homeostasis in Candida Glabrata.Scientific reports · 2017Article
- HAL2 overexpression induces iron acquisition in bdf1Δ cells and enhances their salt resistance.Current genetics · 2017Article
- Leu1 plays a role in iron metabolism and is required for virulence in Cryptococcus neoformans.Fungal genetics and biology : FG & B · 2015Article
- The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess.The EMBO journal · 2014Article
- A chemical potentiator of copper-accumulation used to investigate the iron-regulons of Saccharomyces cerevisiae.Molecular microbiology · 2014Article
- Post-transcriptional regulation of iron homeostasis in Saccharomyces cerevisiae.International journal of molecular sciences · 2013Review
- Negative feedback regulation of the yeast CTH1 and CTH2 mRNA binding proteins is required for adaptation to iron deficiency and iron supplementation.Molecular and cellular biology · 2013Article
- Cross-species transcriptional network analysis reveals conservation and variation in response to metal stress in cyanobacteria.BMC genomics · 2013Article
- A defect in iron uptake enhances the susceptibility of Cryptococcus neoformans to azole antifungal drugs.Fungal genetics and biology : FG & B · 2012Article
- Metabolic remodeling in iron-deficient fungi.Biochimica et biophysica acta · 2012Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Budding yeast (Saccharomyces cerevisiae) responds to iron deprivation both by Aft1-Aft2-dependent transcriptional activation of genes involved in cellular iron uptake and by Cth1-Cth2-specific degradation of certain mRNAs coding for iron-dependent biosynthetic components. Here, we provide evidence for a novel principle of iron-responsive gene expression. This regulatory mechanism is based on the modulation of transcription through the iron-dependent variation of levels of regulatory metabolites. As an example, the LEU1 gene of branched-chain amino acid biosynthesis is downregulated under iron-limiting conditions through depletion of the metabolic intermediate alpha-isopropylmalate, which functions as a key transcriptional coactivator of the Leu3 transcription factor. Synthesis of alpha-isopropylmalate involves the iron-sulfur protein Ilv3, which is inactivated under iron deficiency. As another example, decreased mRNA levels of the cytochrome c-encoding CYC1 gene under iron-limiting conditions involve heme-dependent transcriptional regulation via the Hap1 transcription factor. Synthesis of the iron-containing heme is directly correlated with iron availability. Thus, the iron-responsive expression of genes that are downregulated under iron-limiting conditions is conferred by two independent regulatory mechanisms: transcriptional regulation through iron-responsive metabolites and posttranscriptional mRNA degradation. Only the combination of the two processes provides a quantitative description of the response to iron deprivation in yeast.
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