ArticleEndocrinology2010
Use of mutant mouse lines to investigate origin of gonadotropin-releasing hormone-1 neurons: lineage independent of the adenohypophysis.
Article in Endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Hidden 'pit'falls in deciphering the gonadotropin releasing hormone neuroendocrine cell lineage.Journal of neuroendocrinology · 2021Review
- Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Heterogeneous Origin of Gonadotropin Releasing Hormone-1 Neurons in Mouse Embryos Detected by Islet-1/2 Expression.Frontiers in cell and developmental biology · 2020Article
- GnRH, anosmia and hypogonadotropic hypogonadism--where are we?Frontiers in neuroendocrinology · 2015Review
- Progressive effects of N-myc deficiency on proliferation, neurogenesis, and morphogenesis in the olfactory epithelium.Developmental neurobiology · 2014Article
- Neural crest and placode interaction during the development of the cranial sensory system.Developmental biology · 2014Review
- Article
- Ontogenesis of gonadotropin-releasing hormone neurons: a model for hypothalamic neuroendocrine cell development.Frontiers in endocrinology · 2013Article
- Neural crest and olfactory system: new prospective.Molecular neurobiology · 2012Review
- Specification of GnRH-1 neurons by antagonistic FGF and retinoic acid signaling.Developmental biology · 2012Article
- Neural crest and ectodermal cells intermix in the nasal placode to give rise to GnRH-1 neurons, sensory neurons, and olfactory ensheathing cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Acquisition of spontaneous electrical activity during embryonic development of gonadotropin-releasing hormone-3 neurons located in the terminal nerve of transgenic zebrafish (Danio rerio).General and comparative endocrinology · 2010Article
- From nose to brain: development of gonadotrophin-releasing hormone-1 neurones.Journal of neuroendocrinology · 2010Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Mutant mouse lines have been used to study the development of specific neuronal populations and brain structures as well as behaviors. In this report, single- and double-mutant mice were used to examine the lineage of GnRH-1 cells. GnRH is essential for vertebrate reproduction, with either GnRH-1 or GnRH-3 controlling release of gonadotropins from the anterior pituitary, depending on the species. It is clear that the neuroendocrine GnRH cells migrate from extracentral nervous system locations into the forebrain. However, the embryonic origin of GnRH-1 and GnRH-3 cells is controversial and has been suggested to be nasal placode, adenohypophyseal (anterior pituitary) placode, or neural crest, again dependent on the species examined. We found that mutant mice with either missing or disrupted anterior pituitaries (Gli2(-/-), Gli1(-/-)Gli2(-/-), and Lhx3(-/-)) exhibit a normal GnRH-1 neuronal population and that these cells are still found associated with the developing vomeronasal organ. These results indicate that in mice, GnRH-1 cells develop independent of the adenohypophyseal placode and are associated early with the formation of the nasal placode.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.