Trial reportDiabetes care2010
Real-time continuous glucose monitoring in critically ill patients: a prospective randomized trial.
Trial report in Diabetes care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 105 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Evaluation of Glycaemic Control in the Medical Intensive Care Unit Using Continuous Glucose Monitoring (REGIMEN Trial)
Implementation of Networked Continuous Glucose Monitoring With Telemetry Within the Intensive Care Unit (ICU-TeleCGM)
Who cites it
105 citing papers in PubMed, 2 syntheses or guidelines pooled it, 200 citations in OpenAlex.
- Effects of Continuous Versus Intermittent Glucose Monitoring in Intensive Care Unit Patients: A Systematic Review With Meta-Analysis.Acta anaesthesiologica Scandinavica · 2026Pooled it
- Continuous Glucose Monitors and Automated Insulin Dosing Systems in the Hospital Consensus Guideline.Journal of diabetes science and technology · 2020Guideline
- Insulin-Based Infusion System: Advancing the Development.Journal of diabetes science and technology · 2019Trial
- Targeting glucose control in preterm infants: pilot studies of continuous glucose monitoring.Archives of disease in childhood. Fetal and neonatal edition · 2019Trial
- Trial
- Accuracy of 2 Different Continuous Glucose Monitoring Systems in Patients Undergoing Cardiac Surgery.Journal of diabetes science and technology · 2017Trial
- Blood Glucose Levels of Subelite Athletes During 6 Days of Free Living.Journal of diabetes science and technology · 2016Trial
- Accuracy of a novel noninvasive transdermal continuous glucose monitor in critically ill patients.Journal of diabetes science and technology · 2014Trial
- Insulin treatment guided by subcutaneous continuous glucose monitoring compared to frequent point-of-care measurement in critically ill patients: a randomized controlled trial.Critical care (London, England) · 2014Trial
- LOGIC-insulin algorithm-guided versus nurse-directed blood glucose control during critical illness: the LOGIC-1 single-center, randomized, controlled clinical trial.Diabetes care · 2013Trial
- Evaluation of a continuous blood glucose monitoring system using central venous microdialysis.Journal of diabetes science and technology · 2012Trial
- Glycemic variability and glucose complexity in critically ill patients: a retrospective analysis of continuous glucose monitoring data.Critical care (London, England) · 2012Trial
- Value of continuous glucose monitoring for minimizing severe hypoglycemia during tight glycemic control.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2011Trial
- Feasibility and accuracy of continuous glucose monitoring in surgical intensive care unit patients : a single-center pilot study in South Korea.Acute and critical care · 2026Article
- Endocrinologist-led glucose management in the emergency ICU: a retrospective before-after study.Frontiers in endocrinology · 2026Article
- Association of continuous glucose monitoring with in-hospital adverse outcomes among critically ill patients: a real-world propensity score-matched study.Frontiers in endocrinology · 2026Article
- Advances in the management of hyperglycaemia and diabetes mellitus during hospitalization.Nature reviews. Endocrinology · 2025Review
- A Clinical Review of Continuous Glucose Monitoring in the Hospital Setting.TouchREVIEWS in endocrinology · 2025Article
- Continuous glucose monitoring during intravenous insulin infusion treatment: Assessing accuracy to enable future clinical utility.Diabetic medicine : a journal of the British Diabetic Association · 2025Observational
- Dexcom G7 Accuracy and Reproducibility in the Intensive Care Unit.Diabetes technology & therapeutics · 2025Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE To evaluate the impact of real-time continuous glucose monitoring (CGM) on glycemic control and risk of hypoglycemia in critically ill patients. RESEARCH DESIGN AND METHODS A total 124 patients receiving mechanical ventilation were randomly assigned to the real-time CGM group (n = 63; glucose values given every 5 min) or to the control group (n = 61; selective arterial glucose measurements according to an algorithm; simultaneously blinded CGM) for 72 h. Insulin infusion rates were guided according to the same algorithm in both groups. The primary end point was percentage of time at a glucose level <110 mg/dl. Secondary end points were mean glucose levels and rate of severe hypoglycemia (<40 mg/dl). RESULTS Percentage of time at a glucose level <110 mg/dl (59.0 +/- 20 vs. 55.0 +/- 18% in the control group, P = 0.245) and the mean glucose level (106 +/- 18 vs. 111 +/- 10 mg/dl in the control group, P = 0.076) could not be improved using real-time CGM. The rate of severe hypoglycemia was lower in the real-time CGM group (1.6 vs. 11.5% in the control group, P = 0.031). CGM reduced the absolute risk of severe hypoglycemia by 9.9% (95% CI 1.2-18.6) with a number needed to treat of 10.1 (95% CI 5.4-83.3). CONCLUSIONS In critically ill patients, real-time CGM reduces hypoglycemic events but does not improve glycemic control compared with intensive insulin therapy guided by an algorithm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.