ArticleAmerican journal of respiratory and critical care medicine2010
A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations.
Article in American journal of respiratory and critical care medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- No Significant Effect of ASAP1 Gene Variants on the Susceptibility to Tuberculosis in Chinese Population.Medicine · 2016Pooled it
- Article
- Research progress on genetic control of host susceptibility to tuberculosis.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2022Review
- The Research Progress of Host Genes and Tuberculosis Susceptibility.Oxidative medicine and cellular longevity · 2019Review
- Association of VNTR polymorphism of tumor necrosis factor receptor 2 (Molecular biology research communications · 2017Article
- Comparison of single nucleotide polymorphisms [SNP] at TNF-α promoter region with TNF receptor 2 (TNFR2) in susceptibility to pulmonary tuberculosis; using PCR-RFLP technique.American journal of clinical and experimental immunology · 2016Article
- The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene.PLoS genetics · 2015Article
- A panel of ancestry informative markers for the complex five-way admixed South African coloured population.PloS one · 2013Article
- Innate immune gene polymorphisms in tuberculosis.Infection and immunity · 2012Review
- Genetic variation in the TNF gene is associated with susceptibility to severe sepsis, but not with mortality.PloS one · 2012Article
- Understanding latent tuberculosis: a moving target.Journal of immunology (Baltimore, Md. : 1950) · 2010Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
rationaleSusceptibility to tuberculosis is not only determined by Mycobacterium tuberculosis infection, but also by the genetic component of the host. The pleiotropic cytokine tumor necrosis factor-alpha is essential to control tuberculosis infection, and various tumor necrosis factor family members and their respective receptors may contribute to tuberculosis risk.
objectivesTo investigate four functionally relevant polymorphisms in the tumor necrosis factor receptor 2-encoding gene, tumor necrosis factor receptor superfamily member 1B, for association with tuberculosis susceptibility.
methodsGenotyping of four polymorphisms was performed in independent populations from South Africa (429 cases and 482 control subjects) and Ghana (640 cases and 1,158 control subjects), and the association of the variants with tuberculosis was tested using two case-control association studies. MEASUREMENTS AND MAIN
resultsSingle-point and haplotype analysis in South Africans revealed an association in the 3'untranslated region of the investigated gene. The T allele of rs3397 alone and/or the 3' untranslated region haplotype GTT may confer protection against tuberculosis insofar as both allele and haplotype frequencies were significantly lower in case subjects than in controls. The GTT genotype had previously been shown to increase the decay of tumor necrosis factor receptor 2 messenger ribonucleic acid, and messenger ribonucleic acid destabilization may represent a key molecular mechanism for disease susceptibility. Interestingly, the association signal appeared to be restricted to women. The genetic finding was validated in female participants from Ghana. The combined P value in the haplotype analysis was P = 0.00011.
conclusionsOur finding emphasizes the importance of tumor necrosis factor/tumor necrosis factor receptor-mediated immune responses in the pathogenesis of tuberculosis.
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