Trial reportAJNR. American journal of neuroradiology2010
High-b-value diffusion MR imaging and basal nuclei apparent diffusion coefficient measurements in variant and sporadic Creutzfeldt-Jakob disease.
Trial report in AJNR. American journal of neuroradiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Diagnostic value of diffusion-weighted brain magnetic resonance imaging in patients with sporadic Creutzfeldt-Jakob disease: a systematic review and meta-analysis.European radiology · 2021Pooled it
- Evolution of Diffusion-Weighted Magnetic Resonance Imaging Signal Abnormality in Sporadic Creutzfeldt-Jakob Disease, With Histopathological Correlation.JAMA neurology · 2016Trial
- Diagnostic accuracy of diffusion-weighted imaging in variant Creutzfeldt-Jakob disease.Neuroradiology · 2023Article
- A pilot [Brain, behavior, & immunity - health · 2021Article
- Putaminal diffusion tensor imaging measures predict disease severity across human prion diseases.Brain communications · 2020Article
- Prion disease diagnosis using subject-specific imaging biomarkers within a multi-kernel Gaussian process.NeuroImage. Clinical · 2019Article
- Imaging and CSF analyses effectively distinguish CJD from its mimics.Journal of neurology, neurosurgery, and psychiatry · 2018Article
- Apparent diffusion coefficient maps obtained from high b value diffusion-weighted imaging in the preoperative evaluation of gliomas at 3T: comparison with standard b value diffusion-weighted imaging.European radiology · 2017Article
- Benefit of 3T Diffusion-weighted Imaging in Comparison to Contrast-enhanced MR Imaging for the Evaluation of Disseminated Lesions in Primary Malignant Brain Tumors.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2017Article
- Neuroradiology of human prion diseases, diagnosis and differential diagnosis.La Radiologia medica · 2017Review
- Preoperative grading of supratentorial nonenhancing gliomas by high b-value diffusion-weighted 3 T magnetic resonance imaging.Journal of neuro-oncology · 2017Article
- Neuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry study.NeuroImage. Clinical · 2017Article
- A comparison of high b-value vs standard b-value diffusion-weighted magnetic resonance imaging at 3.0 T for medulloblastomas.The British journal of radiology · 2015Article
- Investigation of Apparent Diffusion Coefficient from Ultra-high b-Values in Parkinson's Disease.European radiology · 2015Article
- Diffusion-weighted MRI findings and clinical correlations in sporadic Creutzfeldt-Jakob disease.Journal of neurology · 2015Article
- Mathematical models for the diffusion magnetic resonance signal abnormality in patients with prion diseases.NeuroImage. Clinical · 2015Article
- Neuroimaging of rapidly progressive dementias, part 2: prion, inflammatory, neoplastic, and other etiologies.AJNR. American journal of neuroradiology · 2014Review
- Multiparameter MR imaging in the 6-OPRI variant of inherited prion disease.AJNR. American journal of neuroradiology · 2013Article
- Susceptibility of domestic cats to chronic wasting disease.Journal of virology · 2013Article
- MRI findings are often missed in the diagnosis of Creutzfeldt-Jakob disease.BMC neurology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
background and purposeDWI using a standard b-value of 1000 s/mm(2) has emerged as the most sensitive sequence for the diagnosis of CJD. The purpose of this study was to investigate whether DWI at a high b-value (b = 3000 s/mm(2)) and ADC measurements in the basal nuclei improve the diagnosis of vCJD and sCJD compared with visual assessment of DWI at a standard b-value (b = 1000 s/mm(2)). MATERIALS AND
methodsEight patients with vCJD, 9 patients with sCJD, and 5 healthy volunteers underwent DWI at b = 1000 s/mm(2), and 5 vCJD patients, 4 sCJD patients, and 1 growth hormone-related CJD patient underwent DWI at b = 3000 s/mm(2). Two consultant neuroradiologists performed a visual comparison of the b = 1000 and b = 3000 images. Mean MR SI and ADC values were determined for C, P, and DM thalamus ROIs bilaterally at each b-value. SI ratios for each ROI relative to white matter were calculated.
resultsIn 9 out of 10 patients, the higher b-value images were more sensitive to SI change, particularly in cortex and thalamus, with higher SI ratios at b = 3000 in the DM thalamus. For sCJD at b = 1000, we found significantly lower ADC values in the C and P compared with controls (mean C ADC = 587.3 +/- 84.7 mm(2)/s in sCJD patients versus 722.7 +/- 16.6 mm(2)/s in controls; P = .007), and at b = 3000, the differences were more pronounced. In comparison, in vCJD at b = 1000, ADC values were elevated in the Pu (mean Pu ADC = 837.6 +/- 33.0 mm/s(2) in vCJD patients versus 748.0 +/- 17.3 mm/s(2) in controls; P < .001) but failed to reach significance at b = 3000.
conclusionsOur results demonstrate that b = 3000 DWI, being more sensitive to slowly diffusing tissue water, is more sensitive to pathology in sCJD than is conventional DWI. High-b-value DWI increases confidence in the radiologic diagnosis of human prion disease.
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