ArticleJournal of experimental botany2010
Identification of flavone phytoalexins and a pathogen-inducible flavone synthase II gene (SbFNSII) in sorghum.
Article in Journal of experimental botany, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed, 114 citations in OpenAlex.
- Integrated metabolomics and transcriptomics analysis of flavonoids in different parts of Houttuynia cordata.BMC genomics · 2026Article
- Elucidating the growth-promoting factors of Bacillus amyloliquefaciens on rapeseed through metabolomics.BMC plant biology · 2025Article
- Genome-Wide Analysis of the FNSII Gene Family and the Role of CitFNSII-1 in Flavonoid Synthesis in Citrus.Plants (Basel, Switzerland) · 2025Article
- Assessing Genetic Variation inInternational journal of molecular sciences · 2025Article
- Unveiling Metabolic Crosstalk:Metabolites · 2024Article
- Change of Flavonoid Content in Wheatgrass in a Historic Collection of Wheat Cultivars.Antioxidants (Basel, Switzerland) · 2024Article
- Deciphering Aphanomyces euteiches-pea-biocontrol bacterium interactions through untargeted metabolomics.Scientific reports · 2024Article
- Data-Driven Characterization of Metabolome Reprogramming during Early Development of Sorghum Seedlings.Metabolites · 2024Article
- Genome-wide association study of plant color inFrontiers in plant science · 2024Article
- Early and Late Transcriptomic and Metabolomic Responses ofInternational journal of molecular sciences · 2023Article
- Functional characterization of two flavone synthase II members in citrus.Horticulture research · 2023Article
- Regioselective stilbene O-methylations in Saccharinae grasses.Nature communications · 2023Article
- QTL mapping and identification of candidate genes linked to red rot resistance in sugarcane.3 Biotech · 2023Article
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- Biosynthesis and antifungal activity of fungus-induced O-methylated flavonoids in maize.Plant physiology · 2022Article
- Multiomics Analyses of Two Sorghum Cultivars Reveal the Molecular Mechanism of Salt Tolerance.Frontiers in plant science · 2022Article
- Functional Characterization of a Flavone Synthase That Participates in a Kumquat Flavone Metabolon.Frontiers in plant science · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Following inoculation with the anthracnose pathogen Colletotrichum sublineolum, seedlings of the sorghum resistant cultivar SC748-5 showed more rapid and elevated accumulation of luteolin than the susceptible cultivar BTx623. On the other hand, apigenin was the major flavone detected in infected BTx623 seedlings. Luteolin was demonstrated to show stronger inhibition of spore germination of C. sublineolum than apigenin. Because of their pathogen-inducible and antifungal nature, both flavone aglycones are considered sorghum phytoalexins. The key enzyme responsible for flavone biosynthesis has not been characterized in monocots. A sorghum pathogen-inducible gene encoding a cytochrome P450 protein (CYP93G3) in the uncharacterized CYP93G subfamily was identified. Transgenic expression of the P450 gene in Arabidopsis demonstrated that the encoded protein is a functional flavone synthase (FNS) II in planta. The sorghum gene was then termed SbFNSII. It is a single-copy gene located on chromosome 2 and the first FNSII gene characterized in a monocot. Metabolite analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in precursor ion scan mode revealed the accumulation of 2-hydroxynaringenin and 2-hydroxyeriodictyol hexosides in the transgenic Arabidopsis plants. Hence, SbFNSII appears to share a similar catalytic mechanism with the licorice and Medicago truncatula FNSIIs (CYP93B subfamily) by converting flavanones to flavone through the formation of 2-hydroxyflavanones.
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