ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Asynchronous RAG-1 expression during B lymphopoiesis.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
- Explainable graph learning for multimodal single-cell data integration.BMC bioinformatics · 2026Article
- RAG suppresses group 2 innate lymphoid cells.eLife · 2025Article
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- The lymphoid-associated interleukin 7 receptor (IL7R) regulates tissue-resident macrophage development.Development (Cambridge, England) · 2019Article
- At the intersection of DNA damage and immune responses.Nature reviews. Immunology · 2019Review
- FateID infers cell fate bias in multipotent progenitors from single-cell RNA-seq data.Nature methods · 2018Article
- Article
- PU.1 Is Required for the Developmental Progression of Multipotent Progenitors to Common Lymphoid Progenitors.Frontiers in immunology · 2018Article
- V(D)J Recombination Exploits DNA Damage Responses to Promote Immunity.Trends in genetics : TIG · 2017Review
- The development of adult innate lymphoid cells.Current opinion in immunology · 2016Review
- Forging T-Lymphocyte Identity: Intersecting Networks of Transcriptional Control.Advances in immunology · 2016Review
- Novel molecular mechanism for generating NK-cell fitness and memory.European journal of immunology · 2015Review
- The RAG recombinase dictates functional heterogeneity and cellular fitness in natural killer cells.Cell · 2014Article
- Early T-cell progenitors are the major granulocyte precursors in the adult mouse thymus.Blood · 2013Article
- Article
- Article
- TLR stimulation of bone marrow lymphoid precursors from childhood acute leukemia modifies their differentiation potentials.BioMed research international · 2013Article
- Expression of functional P-selectin glycoprotein ligand 1 on hematopoietic progenitors is developmentally regulated.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The role of STAT5 in lymphocyte development and transformation.Current opinion in immunology · 2012Review
- Replenishing B lymphocytes in health and disease.Current opinion in immunology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Changes in cell surface markers and patterns of gene expression are commonly used to construct sequences of events in hematopoiesis. However, the order may not be as rigid as once thought and it is unclear which changes represent the best milestones of differentiation. We developed a fate-mapping model where cells with a history of RAG-1 expression are permanently marked by red fluorescence. This approach is valuable for appreciating lymphoid-lineage relationships without need for irradiation and transplantation. Hematopoietic stem cells (HSC) as well as myeloid and dendritic cell progenitors were unlabeled. Also as expected, most previously identified RAG-1(+) early lymphoid progenitors in bone marrow and all lymphoid-affiliated cells were marked. Of particular interest, there was heterogeneity among canonical common lymphoid progenitors (CLP) in bone marrow. Labeled CLP expressed slightly higher levels of IL-7Ralpha, displayed somewhat less c-Kit, and generated CD19(+) lymphocytes faster than the unlabeled CLP. Furthermore, CLP with a history of RAG-1 expression were much less likely to generate dendritic and NK cells. The RAG-1-marked CLP were lineage stable even when exposed to LPS, while unlabeled CLP were redirected to become dendritic cells in response to this TLR4 ligand. These findings indicate that essential events in B lymphopoiesis are not tightly synchronized. Some progenitors with increased probability of becoming lymphocytes express RAG-1 while still part of the lineage marker-negative Sca-1(+)c-Kit(high) (LSK) fraction. Other progenitors first activate this locus after c-Kit levels have diminished and cell surface IL-7 receptors are detectable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.