ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2010
Acid ceramidase improves the quality of oocytes and embryos and the outcome of in vitro fertilization.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- The bioactive sphingolipid playbook. A primer for the uninitiated as well as sphingolipidologists.Journal of lipid research · 2025Review
- Mechanisms of mitochondrial dysfunction in ovarian aging and potential interventions.Frontiers in endocrinology · 2024Review
- Modified mRNA Therapeutics for Heart Diseases.International journal of molecular sciences · 2022Review
- Clinical significance of serum and follicular fluid ceramide levels in women with low ovarian reserve.Turkish journal of obstetrics and gynecology · 2022Article
- Sphingolipids in embryonic development, cell cycle regulation, and stemness - Implications for polyploidy in tumors.Seminars in cancer biology · 2022Review
- Study on the protective effect and mechanism of Liriodendrin on radiation enteritis in mice.Journal of radiation research · 2022Article
- Follicular fluid lipidomic profiling reveals potential biomarkers of polycystic ovary syndrome: A pilot study.Frontiers in endocrinology · 2022Article
- Alterations of lipid metabolism provide serologic biomarkers for the detection of asymptomatic versus symptomatic COVID-19 patients.Scientific reports · 2021Article
- Altering Sphingolipid Metabolism Attenuates Cell Death and Inflammatory Response After Myocardial Infarction.Circulation · 2020Article
- Mitofusin 1 is required for female fertility and to maintain ovarian follicular reserve.Cell death & disease · 2019Article
- Article
- Enzyme replacement therapy for Farber disease: Proof-of-concept studies in cells and mice.BBA clinical · 2017Article
- Metabolic control of oocyte development: linking maternal nutrition and reproductive outcomes.Cellular and molecular life sciences : CMLS · 2015Review
- Construction of conditional acid ceramidase knockout mice and in vivo effects on oocyte development and fertility.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2012Article
- Prohibitin (PHB) acts as a potent survival factor against ceramide induced apoptosis in rat granulosa cells.Life sciences · 2011Article
- Lysosomal lipid storage diseases.Cold Spring Harbor perspectives in biology · 2011Review
- Harnessing mRNA technology for ischemic heart disease: a review of regenerative and protective therapies.Cardiology plusReview
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
A major challenge of assisted reproduction technologies (ARTs) is to mimic the natural environment required to sustain oocyte and embryo survival. Herein, we show that the ceramide-metabolizing enzyme, acid ceramidase (AC), is expressed in human cumulus cells and follicular fluid, essential components of this environment, and that the levels of this enzyme are positively correlated with the quality of human embryos formed in vitro. These observations led us to develop a new approach for oocyte and embryo culture that markedly improved the outcome of in vitro fertilization (IVF). The addition of recombinant AC (rAC) to human and mouse oocyte culture medium maintained their healthy morphology in vitro. Following fertilization, the number of mouse embryos formed in the presence of rAC also was improved (from approximately 40 to 88%), leading to approximately 5-fold more healthy births. To confirm these observations, immature bovine oocytes were matured in vitro and subjected to IVF in the presence of rAC. Significantly more high-grade blastocysts were formed, and the number of morphologically intact, hatched embryos was increased from approximately 24 to 70%. Overall, these data identify AC as an important component of the in vivo oocyte and embryo environment, and provide a novel technology for enhancing the outcome of assisted fertilization. Eliyahu, E., Shtraizent, N., Martinuzzi, K., Barritt, J., He, X., Wei, H., Chaubal, S., Copperman, A. B., Schuchman, E. H. Acid ceramidase improves the quality of oocytes and embryos and the outcome of in vitro fertilization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.