ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Neuromodulation at single presynaptic boutons of cerebellar parallel fibers is determined by bouton size and basal action potential-evoked Ca transient amplitude.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
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- NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice.Molecular brain · 2019Article
- Long-term depression of presynaptic cannabinoid receptor function at parallel fibre synapses.The Journal of physiology · 2019Article
- Article
- Modulation of Ion Channels in the Axon: Mechanisms and Function.Frontiers in cellular neuroscience · 2019Review
- Prefrontal cortex miR-29b-3p plays a key role in the antidepressant-like effect of ketamine in rats.Experimental & molecular medicine · 2018Article
- Activity-dependent plasticity of presynaptic GABASynapse (New York, N.Y.) · 2018Article
- A Light-Controlled Allosteric Modulator Unveils a Role for mGluFrontiers in cellular neuroscience · 2018Article
- Adenosine AFrontiers in cellular neuroscience · 2017Article
- An evolving view of retinogeniculate transmission.Visual neuroscience · 2017Review
- Hybrid Markov-mass action law model for cell activation by rare binding events: Application to calcium induced vesicular release at neuronal synapses.Scientific reports · 2016Article
- The ubiquitous nature of multivesicular release.Trends in neurosciences · 2015Review
- Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals.Nature communications · 2015Article
- Presynaptic calcium channel inhibition underlies CB₁ cannabinoid receptor-mediated suppression of GABA release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Activation of extrasynaptic NMDARs at individual parallel fiber-molecular layer interneuron synapses in cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The long-term structural plasticity of cerebellar parallel fiber axons and its modulation by motor learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Release properties of individual presynaptic boutons expressed during homosynaptic depression and heterosynaptic facilitation of the Aplysia sensorimotor synapse.Frontiers in cellular neuroscience · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Most presynaptic terminals in the brain contain G-protein-coupled receptors that function to reduce action potential-evoked neurotransmitter release. These neuromodulatory receptors, including those for glutamate, GABA, endocannabinoids, and adenosine, exert a substantial portion of their effect by reducing evoked presynaptic Ca(2+) transients. Many axons form synapses with multiple postsynaptic neurons, but it is unclear whether presynaptic attenuation in these synapses is homogeneous, as suggested by population-level Ca(2+) imaging. We loaded Ca(2+)-sensitive dyes into cerebellar parallel fiber axons and imaged action potential-evoked Ca(2+) transients in individual presynaptic boutons with application of three different neuromodulators and found that adjacent boutons on the same axon showed striking heterogeneity in their strength of attenuation. Moreover, attenuation was predicted by bouton size or basal Ca(2+) response: smaller boutons were more sensitive to adenosine A1 agonist but less sensitive to CB1 agonist, while boutons with high basal action potential-evoked Ca(2+) transient amplitude were more sensitive to mGluR4 agonist. These results suggest that boutons within brief segment of a single parallel fiber axon can have different sensitivities toward neuromodulators and may have different capacities for both short-term and long-term plasticities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.