ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Millisecond timescale disinhibition mediates fast information transmission through an avian basal ganglia loop.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Reward-driven adaptation of movements requires strong recurrent basal ganglia-cortical loops.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- An anatomical substrate of credit assignment in reinforcement learning.bioRxiv : the preprint server for biology · 2025Article
- Disinhibition Is an Essential Network Motif Coordinated by GABA Levels and GABA B Receptors.International journal of molecular sciences · 2024Review
- Neural activity during a simple reaching task in macaques is counter to gating and rebound in basal ganglia-thalamic communication.PLoS biology · 2020Article
- A subcortical circuit linking the cerebellum to the basal ganglia engaged in vocal learning.eLife · 2018Article
- Dopaminergic modulation of basal ganglia output through coupled excitation-inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Naturalistic stimulation drives opposing heterosynaptic plasticity at two inputs to songbird cortex.Nature neuroscience · 2015Article
- Reduced reach-related modulation of motor thalamus neural activity in a rat model of Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Modulation of motoneuron firing by recurrent inhibition in the adult rat in vivo.Journal of neurophysiology · 2014Article
- In vivo recording of single-unit activity during singing in zebra finches.Cold Spring Harbor protocols · 2014Article
- The substantia nigra conveys target-dependent excitatory and inhibitory outputs from the basal ganglia to the thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
- Optogenetic activation of nigral inhibitory inputs to motor thalamus in the mouse reveals classic inhibition with little potential for rebound activation.Frontiers in cellular neuroscience · 2014Article
- Basal ganglia output to the thalamus: still a paradox.Trends in neurosciences · 2013Review
- Functional architecture of the cortico-basal ganglia circuitry during motor task execution: correlations of strength of functional connectivity with neuropsychological task performance among female subjects.Human brain mapping · 2013Article
- The countermanding task revisited: fast stimulus detection is a key determinant of psychophysical performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Singing-related activity in anterior forebrain of male zebra finches reflects courtship motivation for target females.PloS one · 2013Article
- Motor thalamus integration of cortical, cerebellar and basal ganglia information: implications for normal and parkinsonian conditions.Frontiers in computational neuroscience · 2013Review
- Integration of cortical and pallidal inputs in the basal ganglia-recipient thalamus of singing birds.Journal of neurophysiology · 2012Article
- Recurrent interactions between the input and output of a songbird cortico-basal ganglia pathway are implicated in vocal sequence variability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
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4 authors.
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Abstract
Avian song learning shares striking similarities with human speech acquisition and requires a basal ganglia (BG)-thalamo-cortical circuit. Information processing and transmission speed in the BG is thought to be limited by synaptic architecture of two serial inhibitory connections. Propagation speed may be critical in the avian BG circuit given the temporally precise control of musculature during vocalization. We used electrical stimulation of the cortical inputs to the BG to study, with fine time resolution, the functional connectivity within this network. We found that neurons in thalamic and cortical nuclei that are not directly connected with the stimulated area can respond to the stimulation with extremely short latencies. Through pharmacological manipulations, we trace this property back to the BG and show that the cortical stimulation triggers fast disinhibition of the thalamic neurons. Surprisingly, feedforward inhibition mediated by striatal inhibitory neurons onto BG output neurons sometimes precedes the monosynaptic excitatory drive from cortical afferents. The fast feedforward inhibition lengthens a single interspike interval in BG output neurons by just a few milliseconds. This short delay is sufficient to drive a strong, brief increase in firing probability in the target thalamic neurons, evoking short-latency responses. By blocking glutamate receptors in vivo, we show that thalamic responses do not appear to rely on excitatory drive, and we show in a theoretical model that they could be mediated by postinhibitory rebound properties. Such fast signaling through disinhibition and rebound may be a crucial specialization for learning of rapid and temporally precise motor acts such as vocal communication.
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